Organisms throughout biology need to maintain the integrity of their genome. From bacteria
to vertebrates, life has established sophisticated mechanisms to detect and eliminate foreign …

Since the discovery of interferons (IFNs), considerable progress has been made in
describing the nature of the cytokines themselves, the signalling components that direct the …

RNA interference (RNAi) is the process of sequence-specific, post-transcriptional gene
silencing in animals and plants, initiated by double-stranded RNA (dsRNA) that is …

Recent discoveries in the field of innate immunity have highlighted the existence of a family
of nucleic acid-sensing proteins that have similar structural and functional properties. These …

Abstract Dengue virus (DENV 1-4) represents a major emerging arthropod-borne pathogen.
All four DENV serotypes are prevalent in the (sub) tropical regions of the world and infect 50 …

Double-stranded RNA (dsRNA) directs gene-specific, post-transcriptional silencing in many
organisms, including vertebrates, and has provided a new tool for studying gene function …

IFNs are a family of cytokines with pleiotropic biological effects mediated by scores of
responsive genes. IFNs were the first human proteins to be effective in cancer therapy and …

The mammalian interferon (IFN) signaling pathway is a primary component of the innate
antiviral response. As such, viral pathogens have devised multiple mechanisms to …

The interferon (IFN)-inducible 2′-5′-oligoadenylate synthetase (OAS)/RNase L pathway
blocks infections by some types of viruses through cleavage of viral and cellular single …

The 2′-5′ oligoadenylate synthetases (OAS) are interferon-induced antiviral enzymes that
recognize virally produced dsRNA and initiate RNA destabilization through activation of …