The different cell types of an organism share the same DNA, but during cell differentiation
their genomes undergo diverse structural and organizational changes that affect gene …

Chromosomes of eukaryotes adopt highly dynamic and complex hierarchical structures in
the nucleus. The three-dimensional (3D) organization of chromosomes profoundly affects …

Noncoding mutations in cancer genomes are frequent but challenging to interpret. PVT1
encodes an oncogenic lncRNA, but recurrent translocations and deletions in human cancers …

Chromosomal architecture is known to influence gene expression, yet its role in controlling
cell fate remains poorly understood. Reprogramming of somatic cells into pluripotent stem …

Recent studies of genome-wide chromatin interactions have revealed that the human
genome is partitioned into many self-associating topological domains. The boundary …

Genome-wide association studies (GWAS) have reproducibly associated variants within
introns of FTO with increased risk for obesity and type 2 diabetes (T2D),,. Although the …

The functional engagement between an enhancer and its target promoter ensures precise
gene transcription. Understanding the basis of promoter choice by enhancers has important …

Gene expression in mammals is precisely regulated by the combination of promoters and
gene-distal regulatory regions, known as enhancers. Several studies have suggested that …

Gene expression during development and differentiation is regulated in a cell-and stage-
specific manner by complex networks of intergenic and intragenic cis-regulatory elements …