The type I interferonopathies: 10 years on
YJ Crow, DB Stetson - Nature Reviews Immunology, 2022 - nature.com
As brutally demonstrated by the COVID-19 pandemic, an effective immune system is
essential for survival. Developed over evolutionary time, viral nucleic acid detection is a …
essential for survival. Developed over evolutionary time, viral nucleic acid detection is a …
Cellular functions of cGAS-STING signaling
C Chen, P Xu - Trends in cell biology, 2023 - cell.com
Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) senses misplaced genomic,
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …
STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes
Stimulator of interferon genes (STING) is essential for the type I interferon response against
a variety of DNA pathogens. Upon emergence of cytosolic DNA, STING translocates from the …
a variety of DNA pathogens. Upon emergence of cytosolic DNA, STING translocates from the …
Chemical and biomolecular strategies for STING pathway activation in cancer immunotherapy
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2
L Zhang, C Jiang, Y Zhong, K Sun, H **g, J Song… - Nature Cell …, 2023 - nature.com
Evasion of antitumour immunity is a hallmark of cancer. STING, a putative innate immune
signalling adaptor, has a pivotal role in mounting antitumour immunity by coordinating …
signalling adaptor, has a pivotal role in mounting antitumour immunity by coordinating …
The balance of STING signaling orchestrates immunity in cancer
KRB Lanng, EL Lauridsen, MR Jakobsen - Nature Immunology, 2024 - nature.com
Over the past decade, it has become clear that the stimulator of interferon genes (STING)
pathway is critical for a variety of immune responses. This endoplasmic reticulum-anchored …
pathway is critical for a variety of immune responses. This endoplasmic reticulum-anchored …
Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy
Z Zhang, H Zhou, X Ouyang, Y Dong… - Signal transduction and …, 2022 - nature.com
Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING
R Fang, Q Jiang, X Jia, Z Jiang - Immunity, 2023 - cell.com
The cGAS-STING pathway mediates cytoplasmic DNA-triggered innate immunity. STING
activation is initiated by cyclic-GMP-AMP (cGAMP)-induced translocation from the …
activation is initiated by cyclic-GMP-AMP (cGAMP)-induced translocation from the …
Organellar homeostasis and innate immune sensing
A cell is delimited by numerous borders that define specific organelles. The walls of some
organelles are particularly robust, such as in mitochondria or endoplasmic reticulum, but …
organelles are particularly robust, such as in mitochondria or endoplasmic reticulum, but …
The STING phase-separator suppresses innate immune signalling
X Yu, L Zhang, J Shen, Y Zhai, Q Jiang, M Yi… - Nature Cell …, 2021 - nature.com
Biomolecular condensates (biocondensates) formed via liquid–liquid phase-separation of
soluble proteins have been studied extensively. However, neither the phase-separation of …
soluble proteins have been studied extensively. However, neither the phase-separation of …