How the immense population of neurons that constitute the human cerebral neocortex is
generated from progenitors lining the cerebral ventricle and then distributed to appropriate …

Lineage studies conducted in the retina more than 25 years ago demonstrated the
multipotency of retinal progenitor cells (RPCs). The number and types of cells produced by …

Multipotential CNS stem cells receive and implement instructions governing differentiation to
diverse neutonal and glial fates. Exploration of the mechanisms generating the many cell …

The vast diversity of neurons and glia of the CNS is generated from a small, heterogeneous
population of progenitors that undergo transcriptional changes during development to …

In the vertebrate central nervous system, multipotential cells have been identified in vitro and
in vivo. Defined mitogens cause the proliferation of multipotential cells in vitro, the …

A mechanism by which members of the ciliary neurotrophic factor (CNTF)–leukemia
inhibitory factor cytokine family regulate gliogenesis in the develo** mammalian central …

The process wherein dividing cells exhaust proliferative capacity and enter into replicative
senescence has become a prominent model for cellular aging in vitro. Despite decades of …

In the vertebrate central nervous system, the retina has been a useful model for studies of
cell fate determination. Recent results from studies conducted in vitro and in vivo suggest a …

Postmitotic neurons are produced from a pool of cycling progenitors in an orderly fashion
during development. Studies of cell-fate determination in the vertebrate retina have …

The molecular mechanisms mediating the retinogenic potential of multipotent retinal
progenitor cells (RPCs) are poorly defined. Prior to initiating retinogenesis, RPCs express a …