Cerebral small vessel disease (SVD) is commonly observed on neuroimaging among
elderly individuals and is recognized as a major vascular contributor to dementia, cognitive …

Longitudinal clinical–pathological studies have increasingly recognized the importance of
mixed pathologies (the coexistence of one or more neurodegenerative and cerebrovascular …

White matter hyperintensities (WMH) of presumed vascular origin, also referred to as
leukoaraiosis, are a very common finding on brain magnetic resonance imaging (MRI) or …

Cerebral small vessel disease (CSVD) is a very common neurological disease in older
people. It causes stroke and dementia, mood disturbance and gait problems. Since it is …

Introduction Small vessel disease (SVD) is a common contributor to dementia. Subtle blood-
brain barrier (BBB) leakage may be important in SVD-induced brain damage. Methods We …

Vascular cognitive impairment (VCI) is the diagnostic term used to describe a
heterogeneous group of sporadic and hereditary diseases of the large and small blood …

White matter hyperintensities accumulate with age and occur in patients with stroke, but their
pathogenesis is poorly understood. We measured multiple magnetic resonance imaging …

Aortic stiffness is associated with cognitive decline and cerebrovascular disease late in life,
although these associations have not been examined in young adults. Understanding the …

Vascular cognitive impairment (VCI) is a lifelong process encompassing a broad spectrum of
cognitive disorders, ranging from subtle or mild deficits to prodromal and fully developed …

Background and Purpose—Previous reports from the Framingham Heart Study have
identified cross-sectional associations of arterial stiffness, as reflected by carotid–femoral …