Background: Preservation of brain health has emerged as a leading public health priority for
the aging world population. Advances in neurovascular biology have revealed an intricate …

There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and
several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical …

Blood microcirculation supplies neurons with oxygen and nutrients, and contributes to
clearing their neurotoxic waste, through a dense capillary network connected to larger tree …

The unceasing metabolic demands of brain function are supported by an intricate three‐
dimensional network of arterioles, capillaries, and venules, designed to effectively distribute …

Despite the key role of the capillaries in neurovascular function, a thorough characterization
of cerebral capillary network properties is currently lacking. Here, we define a range of …

Sickle cell anemia is a unique disease dominated by hemolytic anemia and vaso-occlusive
events. The latter trigger a version of ischemia/reperfusion (I/R) pathobiology that is singular …

Vascular dementia (VaD) constitutes the second most prevalent cause of dementia in the
world after Alzheimer's disease (AD). VaD regroups heterogeneous neurological conditions …

Cerebral microinfarcts (CMIs) are small ischemic lesions invisible to the naked eye at brain
autopsy, while the larger ones (0.5–4 mm in diameter) have been visualized in-vivo on …

There has been an increasing appreciation of the role of vascular contributions to cognitive
impairment and dementia (VCID) associated with old age. Strong preclinical and …

The relationship between amyloidosis and vasculature in cognitive impairment and
Alzheimer's disease (AD) pathogenesis is increasingly acknowledged. We conducted a …