Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …

NAD+-dependent deacetylase sirtuin-1 (Sirt1) belongs to the sirtuins family, known to be
longevity regulators, and exerts a key role in the prevention of vascular aging. By aging, the …

The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical
age-related conditions that significantly impact health. Vascular impairment disrupts blood …

How endothelial cells sense and respond to dynamic changes in their biophysical
surroundings as we age is not fully understood. Vascular stiffness is clearly a contributing …

Preservation of brain health is a worldwide priority. The traditional view is that the major
threats to the ageing brain lie within the brain itself. Consequently, therapeutic approaches …

Cellular senescence, a characteristic sign of aging, classically refers to permanent cell
proliferation arrest and is a vital contributor to the pathogenesis of cancer and age-related …

Background Accumulating evidence suggests that autonomic dysfunction and persistent
systemic inflammation are common clinical features in myalgic encephalomyelitis/chronic …

Cardiovascular aging presents a formidable challenge, as the aging process can lead to
reduced cardiac function and heightened susceptibility to cardiovascular diseases …

Neuroinflammation is an innate and adaptive immune response initiated by the release of
inflammatory mediators from various immune cells in response to harmful stimuli. While …

Diabetic retinopathy (DR) is a diabetic complication that results in visual impairment and
relevant retinal diseases. Current therapeutic strategies on DR primarily focus on …