Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase
Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
Insights into the structure activity relationship of nitrogen-containing heterocyclics for the development of antidepressant compounds: An updated review
Abstract According to the World Health Organization (WHO), depression is a common
mental disorder and includes complex interaction between social and psychological …
mental disorder and includes complex interaction between social and psychological …
Design, Synthesis, and Pharmacological Evaluation of N-Propargylated Diphenylpyrimidines as Multitarget Directed Ligands for the Treatment of Alzheimer's Disease
Alzheimer's disease (AD), a multifactorial complex neural disorder, is categorized with
progressive memory loss and cognitive impairment as main clinical features. The multitarget …
progressive memory loss and cognitive impairment as main clinical features. The multitarget …
Design, synthesis and biological evaluation of new benzoxazolone/benzothiazolone derivatives as multi-target agents against Alzheimer's disease
In this study, four series of compounds with benzoxazolone and benzothiazolone cores were
designed, synthesized and evaluated as multifunctional agents against Alzheimer's disease …
designed, synthesized and evaluated as multifunctional agents against Alzheimer's disease …
An insight on medicinal attributes of pyrimidine scaffold: An updated review
A Vyas, B Sahu, S Pathania, NK Nandi… - Journal of …, 2023 - Wiley Online Library
Pyrimidine itself or in different fused forms is an important chemical motif for every step of
cell life. Alongside, it exists as a key pharmacophoric part in thiamine, alloxan, orotic acid …
cell life. Alongside, it exists as a key pharmacophoric part in thiamine, alloxan, orotic acid …
Multi-target-directed ligands as an effective strategy for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a complex neurological disorder and multiple pathological
factors are believed to be involved in the genesis and progression of the disease. A number …
factors are believed to be involved in the genesis and progression of the disease. A number …
Synthesis, in vitro and docking studies of 2-substituted 5, 6, 7, 8-tetrahydrobenzo [4, 5] thieno [2, 3-d] pyrimidine-4 (3H)-one derivatives as agents for the treatment of …
AS Chiriapkin, IP Kodonidi, DI Pozdnyakov… - Chimica Techno …, 2022 - journals.urfu.ru
Alzheimer's disease is a chronic neurodegenerative disease, which is characterized mainly
by a progressive decrease in intellectual abilities, memory impairment and a change in a …
by a progressive decrease in intellectual abilities, memory impairment and a change in a …
A review on the arylpiperazine derivatives as potential therapeutics for the treatment of various neurological disorders
Neurological disorders are disease conditions related to the neurons and central nervous
system (CNS). Any structural, electrical, biochemical, and functional abnormalities in …
system (CNS). Any structural, electrical, biochemical, and functional abnormalities in …
Investigation of Indole‐3‐piperazinyl Derivatives as Potential Antidepressants: Design, Synthesis, In‐Vitro, In‐Vivo and In‐Silico Analysis
Depression is declared the second leading cause of disability worldwide. Recently, cases of
depression have increased significantly in adolescents, young adults as well as in elder …
depression have increased significantly in adolescents, young adults as well as in elder …
Progress in the study of anti-Alzheimer's disease activity of pyrimidine-containing bioactive molecules
YL Liu, Q Zhang, BQ Li, D Zhang, RH Chui… - European Journal of …, 2025 - Elsevier
Abstracts: Pyrimidines are aromatic, heterocyclic organic compounds characterized by a six-
membered ring that contains four carbon atoms and two nitrogen atoms. They have been …
membered ring that contains four carbon atoms and two nitrogen atoms. They have been …