Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase

RJ Obaid, N Naeem, EU Mughal, MM Al-Rooqi… - RSC …, 2022 - pubs.rsc.org
Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …

Insights into the structure activity relationship of nitrogen-containing heterocyclics for the development of antidepressant compounds: An updated review

K Singh, R Pal, SA Khan, B Kumar, MJ Akhtar - Journal of Molecular …, 2021 - Elsevier
Abstract According to the World Health Organization (WHO), depression is a common
mental disorder and includes complex interaction between social and psychological …

Design, Synthesis, and Pharmacological Evaluation of N-Propargylated Diphenylpyrimidines as Multitarget Directed Ligands for the Treatment of Alzheimer's Disease

B Kumar, AR Dwivedi, T Arora, K Raj… - ACS Chemical …, 2022 - ACS Publications
Alzheimer's disease (AD), a multifactorial complex neural disorder, is categorized with
progressive memory loss and cognitive impairment as main clinical features. The multitarget …

Design, synthesis and biological evaluation of new benzoxazolone/benzothiazolone derivatives as multi-target agents against Alzheimer's disease

M Erdogan, B Kilic, RI Sagkan, F Aksakal… - European Journal of …, 2021 - Elsevier
In this study, four series of compounds with benzoxazolone and benzothiazolone cores were
designed, synthesized and evaluated as multifunctional agents against Alzheimer's disease …

An insight on medicinal attributes of pyrimidine scaffold: An updated review

A Vyas, B Sahu, S Pathania, NK Nandi… - Journal of …, 2023 - Wiley Online Library
Pyrimidine itself or in different fused forms is an important chemical motif for every step of
cell life. Alongside, it exists as a key pharmacophoric part in thiamine, alloxan, orotic acid …

Multi-target-directed ligands as an effective strategy for the treatment of Alzheimer's disease

B Kumar, A Thakur, AR Dwivedi… - Current Medicinal …, 2022 - ingentaconnect.com
Alzheimer's disease (AD) is a complex neurological disorder and multiple pathological
factors are believed to be involved in the genesis and progression of the disease. A number …

Synthesis, in vitro and docking studies of 2-substituted 5, 6, 7, 8-tetrahydrobenzo [4, 5] thieno [2, 3-d] pyrimidine-4 (3H)-one derivatives as agents for the treatment of …

AS Chiriapkin, IP Kodonidi, DI Pozdnyakov… - Chimica Techno …, 2022 - journals.urfu.ru
Alzheimer's disease is a chronic neurodegenerative disease, which is characterized mainly
by a progressive decrease in intellectual abilities, memory impairment and a change in a …

A review on the arylpiperazine derivatives as potential therapeutics for the treatment of various neurological disorders

B Kumar, N Kumar, A Thakur, V Kumar… - Current Drug …, 2022 - ingentaconnect.com
Neurological disorders are disease conditions related to the neurons and central nervous
system (CNS). Any structural, electrical, biochemical, and functional abnormalities in …

Investigation of Indole‐3‐piperazinyl Derivatives as Potential Antidepressants: Design, Synthesis, In‐Vitro, In‐Vivo and In‐Silico Analysis

RR Kumar, V Kumar, D Kaur, NK Nandi… - …, 2021 - Wiley Online Library
Depression is declared the second leading cause of disability worldwide. Recently, cases of
depression have increased significantly in adolescents, young adults as well as in elder …

Progress in the study of anti-Alzheimer's disease activity of pyrimidine-containing bioactive molecules

YL Liu, Q Zhang, BQ Li, D Zhang, RH Chui… - European Journal of …, 2025 - Elsevier
Abstracts: Pyrimidines are aromatic, heterocyclic organic compounds characterized by a six-
membered ring that contains four carbon atoms and two nitrogen atoms. They have been …