We used transient biochemical and structural kinetics to elucidate the molecular mechanism
of mavacamten, an allosteric cardiac myosin inhibitor and a prospective treatment for …

The discovery that mutations in myosin and actin genes, together with mutations in the other
components of the muscle sarcomere, are responsible for a range of inherited muscle …

Hypertrophic cardiomyopathies (HCM) result from distinct single-point mutations in
sarcomeric proteins that lead to muscle hypercontractility. While different models account for …

Cardiac muscle develops more force when it is activated at longer lengths. The
concentration of Ca 2+ required to develop half-maximal force also decreases. These effects …

Abstract Concepts in molecular tension sensing in biology are growing and have their
origins in studies of muscle contraction. In the heart muscle, a key parameter of contractility …

Background Recent studies suggest that mavacamten (Myk461), a small myosin‐binding
molecule, decreases hypercontractility in myocardium expressing hypertrophic …

Transgenic mouse models have been important tools for studying the relationship of
genotype to phenotype for human diseases, including those of skeletal muscle. We show …

Hypertrophic cardiomyopathy (HCM) is a common genetic disorder characterized by left
ventricular hypertrophy and cardiac hyper-contractility. Mutations in the β-cardiac myosin …

Hypertrophic cardiomyopathy (HCM) is a genetic disease of the heart characterized by
thickening of the left ventricle (LV), hypercontractility, and impaired relaxation. HCM is …

One of our clinical colleagues once told us,“There are PhD problems, and there are
important problems. You should work on important problems.” We reject our colleague's …