Scientific, sustainability and regulatory challenges of cultured meat

MJ Post, S Levenberg, DL Kaplan, N Genovese, J Fu… - Nature Food, 2020 - nature.com
Cellular agriculture is an emerging branch of biotechnology that aims to address issues
associated with the environmental impact, animal welfare and sustainability challenges of …

Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution

AA Pollen, U Kilik, CB Lowe, JG Camp - Nature Reviews Genetics, 2023 - nature.com
Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …

[HTML][HTML] A single-cell atlas of chromatin accessibility in the human genome

K Zhang, JD Hocker, M Miller, X Hou, J Chiou… - Cell, 2021 - cell.com
Current catalogs of regulatory sequences in the human genome are still incomplete and lack
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …

A serum-free media formulation for cultured meat production supports bovine satellite cell differentiation in the absence of serum starvation

T Messmer, I Klevernic, C Furquim, E Ovchinnikova… - Nature Food, 2022 - nature.com
Cultured meat production requires the robust differentiation of satellite cells into mature
muscle fibres without the use of animal-derived components. Current protocols induce …

Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma

S Jansky, AK Sharma, V Körber, A Quintero… - Nature …, 2021 - nature.com
Neuroblastoma is a pediatric tumor of the develo** sympathetic nervous system.
However, the cellular origin of neuroblastoma has yet to be defined. Here we studied the …

Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids

SC van den Brink, A Alemany, V van Batenburg… - Nature, 2020 - nature.com
Gastruloids are three-dimensional aggregates of embryonic stem cells that display key
features of mammalian development after implantation, including germ-layer specification …

Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites

JV Veenvliet, A Bolondi, H Kretzmer, L Haut… - Science, 2020 - science.org
INTRODUCTION Vertebrate development comprises multiple complex morphogenetic
processes that shape the embryonic body plan through self-organization of pluripotent stem …

Self-organizing 3D human trunk neuromuscular organoids

JMF Martins, C Fischer, A Urzi, R Vidal, S Kunz… - Cell stem cell, 2020 - cell.com
Neuromuscular networks assemble during early human embryonic development and are
essential for the control of body movement. Previous neuromuscular junction modeling …

Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution

M Dos Santos, AM Shah, Y Zhang… - Nature …, 2023 - nature.com
Skeletal muscle fibers express distinct gene programs during development and maturation,
but the underlying gene regulatory networks that confer stage-specific myofiber properties …

Tissue engineering for clean meat production

T Ben-Arye, S Levenberg - Frontiers in Sustainable Food Systems, 2019 - frontiersin.org
Increasing public awareness of foodborne illnesses, factory farming, and the ecological
footprint of the meat industry, has generated the need for animal-free meat alternatives. In …