Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation
Z Bekassy, I Lopatko Fagerström, M Bader… - Nature Reviews …, 2022 - nature.com
During severe inflammatory and infectious diseases, various mediators modulate the
equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review …
equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review …
[HTML][HTML] Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets
Deciphering the molecular downstream consequences of severe acute respiratory
syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of …
syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of …
[HTML][HTML] Complement activation in COVID-19 and targeted therapeutic options: a sco** review
Increasing evidence suggests that activation of the complement system plays a key role in
the pathogenesis and disease severity of Coronavirus disease 2019 (COVID-19). We used a …
the pathogenesis and disease severity of Coronavirus disease 2019 (COVID-19). We used a …
Role of the renin–angiotensin–aldosterone and kinin–kallikrein systems in the cardiovascular complications of COVID-19 and long COVID
SL Cooper, E Boyle, SR Jefferson, CRA Heslop… - International Journal of …, 2021 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the virus responsible
for the COVID-19 pandemic. Patients may present as asymptomatic or demonstrate mild to …
for the COVID-19 pandemic. Patients may present as asymptomatic or demonstrate mild to …
Plasma angiotensin II is increased in critical coronavirus disease 2019
RL Camargo, B Bombassaro… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) employs angiotensin-
converting enzyme 2 (ACE2) as its receptor for cell entrance, and studies have suggested …
converting enzyme 2 (ACE2) as its receptor for cell entrance, and studies have suggested …
Function and structure of bradykinin receptor 2 for drug discovery
J Shen, H Zhang - Acta Pharmacologica Sinica, 2023 - nature.com
Type 2 bradykinin receptor (B2R) is an essential G protein-coupled receptor (GPCR) that
regulates the cardiovascular system as a vasodepressor. Dysfunction of B2R is also closely …
regulates the cardiovascular system as a vasodepressor. Dysfunction of B2R is also closely …
Contact and intrinsic coagulation pathways are activated and associated with adverse clinical outcomes in COVID-19
MW Henderson, F Lima, CRP Moraes, A Ilich… - Blood …, 2022 - ashpublications.org
Coagulation activation is a prominent feature of severe acute respiratory syndrome
coronavirus 2 (COVID-19) infection. Activation of the contact system and intrinsic pathway …
coronavirus 2 (COVID-19) infection. Activation of the contact system and intrinsic pathway …
Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19
CP Martens, P Van Mol, J Wauters, E Wauters… - …, 2022 - thelancet.com
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the
angiotensin-converting enzyme 2 (ACE2) receptor, a critical component of the kallikrein …
angiotensin-converting enzyme 2 (ACE2) receptor, a critical component of the kallikrein …
How the innate immune system of the blood contributes to systemic pathology in COVID-19-induced ARDS and provides potential targets for treatment
Most SARS-CoV-2 infected patients experience influenza-like symptoms of low or moderate
severity. But, already in 2020 early during the pandemic it became obvious that many …
severity. But, already in 2020 early during the pandemic it became obvious that many …
Drugs modulating renin-angiotensin system in COVID-19 treatment
JL Labandeira-Garcia, CM Labandeira, R Valenzuela… - Biomedicines, 2022 - mdpi.com
A massive worldwide vaccination campaign constitutes the main tool against the COVID-19
pandemic. However, drug treatments are also necessary. Antivirals are the most frequently …
pandemic. However, drug treatments are also necessary. Antivirals are the most frequently …