NF-κB (nuclear factor-κB) is a collective name for inducible dimeric transcription factors
composed of members of the Rel family of DNA-binding proteins that recognize a common …

▪ Abstract Successful viral replication requires not only the efficient production and spread of
progeny, but also evasion of host defense mechanisms that limit replication by killing …

Nuclear factor kappa B (NF-κB)/Rel proteins are dimeric, sequence-specific transcription
factors involved in the activation of an exceptionally large number of genes in response to …

Adenovirus (Ad) infection is concluded by assembly of virions in the cell nucleus followed by
lysis of cells by an unknown mechanism. We have described an Ad nuclear membrane …

The immune system provides good models for cell death, a phenomenon now recognized to
be of fundamental importance in many fields of biology. Cell death is strikingly polymorphic …

Coexistence of viruses and their hosts imposes an evolutionary pressure on both the virus
and the host immune system. On the one hand, the host has developed an immune system …

Neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal
dementia, and glaucoma, affect millions of people worldwide. ALS is caused by the loss of …

In the evolutionary battle between viruses and their hosts, viruses have armed themselves
with weapons to defeat the host's attacks on infected cells. Various proteins encoded in the …

High risk strains of human papillomavirus (HPV), such as HPV 16, cause human cervical
carcinoma. The E6 protein of HPV 16 mediates the rapid degradation of p53, although this is …

ABSTRACT Early region 3 (E3) of group C human adenoviruses (Ad) encodes several
inhibitors of tumor necrosis factor alpha (TNF-α) cytolysis, including an E3 14.7-kDa protein …