Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

Obesity is one of the major health burdens of the 21st century as it contributes to the growing
prevalence of its related comorbidities, including insulin resistance and type 2 diabetes …

The consumption of Western-type calorically rich diets combined with chronic overnutrition
and a sedentary lifestyle in Western societies evokes a state of chronic metabolic …

MiRNAs are regulatory molecules that can be packaged into exosomes and secreted from
cells. Here, we show that adipose tissue macrophages (ATMs) in obese mice secrete …

Nonalcoholic fatty liver disease (NAFLD) and its inflammatory and often progressive subtype
nonalcoholic steatohepatitis (NASH) are becoming the leading cause of liver-related …

Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

Macrophages have diverse phenotypes and functions due to differences in their origin,
location and pathophysiological context. Although their main role in the liver has been …

Stress-linked psychiatric disorders, including anxiety and major depressive disorder, are
associated with systemic inflammation. Recent studies have reported stress-induced …

Obesity is the most common cause of insulin resistance, and the current obesity epidemic is
driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic …

Palmitic acid is a saturated fatty acid whose blood concentration is elevated in obese
patients. This causes inflammatory responses, where toll-like receptors (TLR), TLR2 and …