Survey and perspective on verification, validation, and uncertainty quantification of digital twins for precision medicine
Digital twins in precision medicine provide tailored health recommendations by simulating
patient-specific trajectories and interventions. We examine the critical role of Verification …
patient-specific trajectories and interventions. We examine the critical role of Verification …
Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
P Dominguez-Gomez, A Zingaro, L Baldo-Canut… - npj Digital …, 2024 - nature.com
In silico trials for drug safety assessment require many high-fidelity 3D cardiac simulations to
predict drug-induced QT interval prolongation, which is often computationally prohibitive. To …
predict drug-induced QT interval prolongation, which is often computationally prohibitive. To …
Liquid Fourier Latent Dynamics Networks for fast GPU-based numerical simulations in computational cardiology
Scientific Machine Learning (ML) is gaining momentum as a cost-effective alternative to
physics-based numerical solvers in many engineering applications. In fact, scientific ML is …
physics-based numerical solvers in many engineering applications. In fact, scientific ML is …
Cardiac perfusion coupled with a structured coronary network tree
Sufficient myocardial perfusion plays a pivotal role in maintaining normal pump function.
However the development of a comprehensive myocardial perfusion model remains …
However the development of a comprehensive myocardial perfusion model remains …
[HTML][HTML] Advanced statistical inference of myocardial stiffness: A time series Gaussian process approach of emulating cardiac mechanics for real-time clinical decision …
Cardiac mechanics modelling promises to revolutionize personalized health care; however,
inferring patient-specific biophysical parameters, which are critical for understanding …
inferring patient-specific biophysical parameters, which are critical for understanding …
A comparative analysis of metamodels for lumped cardiovascular models, and pipeline for sensitivity analysis, parameter estimation, and uncertainty quantification
Zero-dimensional (0D) cardiovascular models are reduced-order models used to study
global circulation dynamics and transport. They provide estimates of biomarkers (such as …
global circulation dynamics and transport. They provide estimates of biomarkers (such as …
Real-time prediction of drug-induced proarrhythmic risk with sex-specific cardiac emulators
P Dominguez-Gomez, A Zingaro, L Baldo-Canut… - bioRxiv, 2024 - biorxiv.org
In silico trials for drug safety assessment require a large number of high-fidelity 3D cardiac
electrophysiological simulations to predict drug-induced QT interval prolongation, making …
electrophysiological simulations to predict drug-induced QT interval prolongation, making …