Cholangiocytes, the epithelial cells lining the intrahepatic and extrahepatic bile ducts, are
highly specialized cells residing in a complex anatomic niche where they participate in bile …

Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

INTRODUCTION The liver's remarkable capacity to maintain proper tissue mass after injury
has been known since ancient times. However, there has been considerable debate about …

The mammalian liver possesses a remarkable regenerative ability. Two modes of damage
response have been described:(1) The" oval cell" response emanates from the biliary tree …

Gastric cancer is a major source of global cancer mortality with limited treatment options and
poor patient survival. As our molecular understanding of gastric cancer improves, we are …

Primary liver cancer is the second leading cause of cancer-related death worldwide and
therefore a major public health challenge. We review hypotheses of the cell of origin of liver …

The liver can fully regenerate after partial resection, and its underlying mechanisms have
been extensively studied. The liver can also rapidly regenerate after injury, with most studies …

The steps governing healing with or without fibrosis within the same microenvironment are
unclear. After acute kidney injury (AKI), injured proximal tubular epithelial cells activate …

Transcriptome analysis enables the study of gene expression in human tissues and is a
valuable tool to characterise liver function and gene expression dynamics during liver …

Despite the enormous replication potential of the human liver, there are currently no culture
systems available that sustain hepatocyte replication and/or function in vitro. We have …