Type 1 diabetes in diverse ancestries and the use of genetic risk scores
Over 75 genetic loci within and outside of the HLA region influence type 1 diabetes risk.
Genetic risk scores (GRS), which facilitate the integration of complex genetic information …
Genetic risk scores (GRS), which facilitate the integration of complex genetic information …
Pathogenesis of type 1 diabetes: established facts and new insights
A Zajec, K Trebušak Podkrajšek, T Tesovnik, R Šket… - Genes, 2022 - mdpi.com
Type 1 diabetes (T1D) is an autoimmune disease characterized by the T-cell-mediated
destruction of insulin-producing β-cells in pancreatic islets. It generally occurs in genetically …
destruction of insulin-producing β-cells in pancreatic islets. It generally occurs in genetically …
Genetic variants in the complement system and their potential link in the aetiology of type 1 diabetes
S Onengut‐Gumuscu… - Diabetes/Metabolism …, 2024 - Wiley Online Library
Type 1 diabetes is an autoimmune disease in which one's own immune system destroys
insulin‐secreting beta cells in the pancreas. This process results in life‐long dependence on …
insulin‐secreting beta cells in the pancreas. This process results in life‐long dependence on …
Implementation of type 1 diabetes genetic risk screening in children in diverse communities: the Virginia PrIMeD project
Background Population screening for risk of type 1 diabetes (T1D) has been proposed to
identify those with islet autoimmunity (presence of islet autoantibodies). As islet …
identify those with islet autoimmunity (presence of islet autoantibodies). As islet …
Combining polygenic risk scores and human leukocyte antigen variants for personalized risk assessment of type 1 diabetes in the Taiwanese population
Aims To analyse the genome‐wide association study (GWAS) data of patients with type 1
diabetes mellitus (T1D) in order to develop a risk score for the genetic effects on T1D risk …
diabetes mellitus (T1D) in order to develop a risk score for the genetic effects on T1D risk …
Type 1 Diabetes Genetic Risk Scores: History, Application and Future Directions
Abstract Purpose of Review To review the genetics of type 1 diabetes (T1D) and T1D
genetic risk scores, focusing on their development, research and clinical applications, and …
genetic risk scores, focusing on their development, research and clinical applications, and …
Transcriptome organization of white blood cells through gene co-expression network analysis in a large RNA-seq dataset
P Forabosco, M Pala, F Crobu, MA Diana… - Frontiers in …, 2024 - frontiersin.org
Gene co-expression network analysis enables identification of biologically meaningful
clusters of co-regulated genes (modules) in an unsupervised manner. We present here the …
clusters of co-regulated genes (modules) in an unsupervised manner. We present here the …
Changes in the coexpression of innate immunity genes during persistent islet autoimmunity are associated with progression of islet autoimmunity: Diabetes …
Longitudinal changes in gene expression during islet autoimmunity (IA) may provide insight
into biological processes that explain progression to type 1 diabetes (T1D). We identified …
into biological processes that explain progression to type 1 diabetes (T1D). We identified …
Islet Autoantibody Reversion as a Model of Type One Diabetes Resiliency
PM Carry - 2021 - search.proquest.com
It is generally accepted that islet autoimmunity (IA) onset and progression to T1D involve a
complex interplay of genetic and environmental factors. IA, the pre-clinical phase that is …
complex interplay of genetic and environmental factors. IA, the pre-clinical phase that is …