Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genome
Considerable progress towards an understanding of complex diseases has been made in
recent years due to the development of high-throughput genoty** technologies. Using …
recent years due to the development of high-throughput genoty** technologies. Using …
The role of HOX transcription factors in cancer predisposition and progression
Homeobox (HOX) transcription factors, encoded by a subset of homeodomain superfamily
genes, play pivotal roles in many aspects of cellular physiology, embryonic development …
genes, play pivotal roles in many aspects of cellular physiology, embryonic development …
Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-map** resolution
Trans-ethnic meta-analysis of genome-wide association studies (GWAS) across diverse
populations can increase power to detect complex trait loci when the underlying causal …
populations can increase power to detect complex trait loci when the underlying causal …
Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer
Long noncoding RNAs (lncRNAs) represent an attractive class of candidates to mediate
cancer risk. Through integrative analysis of the lncRNA transcriptome with genomic data and …
cancer risk. Through integrative analysis of the lncRNA transcriptome with genomic data and …
Charting the future of cancer health disparities research: a position statement from the American Association for Cancer Research, the American Cancer Society, the …
The academic field of cancer health disparities was stimulated by the US civil rights
movement. Concerns about civil rights led to concerns about equality in health care. The first …
movement. Concerns about civil rights led to concerns about equality in health care. The first …
Integrative comparison of the genomic and transcriptomic landscape between prostate cancer patients of predominantly African or European genetic ancestry
Men of predominantly African Ancestry (AA) have higher prostate cancer (CaP) incidence
and worse survival than men of predominantly European Ancestry (EA). While …
and worse survival than men of predominantly European Ancestry (EA). While …
Post-GWAS in prostate cancer: from genetic association to biological contribution
Genome-wide association studies (GWAS) have been successful in deciphering the genetic
component of predisposition to many human complex diseases including prostate cancer …
component of predisposition to many human complex diseases including prostate cancer …
A biallelic multiple nucleotide length polymorphism explains functional causality at 5p15. 33 prostate cancer risk locus
To date, single-nucleotide polymorphisms (SNPs) have been the most intensively
investigated class of polymorphisms in genome wide associations studies (GWAS) …
investigated class of polymorphisms in genome wide associations studies (GWAS) …
Fine-map** of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
Prostate cancer is a polygenic disease with a large heritable component. A number of
common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here …
common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here …
CAUSEL: an epigenome-and genome-editing pipeline for establishing function of noncoding GWAS variants
The vast majority of disease-associated single-nucleotide polymorphisms (SNPs) mapped
by genome-wide association studies (GWASs) are located in the non-protein-coding …
by genome-wide association studies (GWASs) are located in the non-protein-coding …