The world continues to contend with successive waves of coronavirus disease 2019 (COVID-
19), fueled by the emergence of viral variants. At the same time, persistent, prolonged and …

The tumor microenvironment (TME) is a critical regulator of tumor growth, progression, and
metastasis. Among the innate immune cells recruited to the tumor site, macrophages are the …

Phagocytosis is a cellular process for ingesting and eliminating particles larger than 0.5 μm
in diameter, including microorganisms, foreign substances, and apoptotic cells …

One hundred years have passed since the death of Élie Metchnikoff (1845–1916). He was
the first to observe the uptake of particles by cells and realized the importance of this …

Various immune mechanisms are deployed in the mucosa to confront the immense diversity
of resident bacteria. A substantial fraction of the commensal microbiota is coated with …

Mouse and human FcRs have been a major focus of attention not only of the scientific
community, through the cloning and characterization of novel receptors, and of the medical …

Antiviral activities of antibodies may either be dependent only on interactions between the
antibody and cognate antigen, as in binding and neutralization of an infectious virion, or …

CD47 is a widely expressed cell surface protein that functions as a regulator of phagocytosis
mediated by cells of the innate immune system, such as macrophages and dendritic cells …

Impressive advances in defining the properties of receptors for the Fc portion of
immunoglobulins (FcR) have been made over the past several years. Ligand specificities …

The generation of tumor-specific lymphocytes and their use in adoptive immunotherapy is
limited to a few malignancies because most spontaneous tumors are very weak or not at all …