Body wasting is a serious complication that affects a large proportion of patients with heart
failure. Muscle wasting, also known as sarcopenia, is the loss of muscle mass and strength …

With aging and other muscle wasting diseases, men and women undergo similar
pathological changes in skeletal muscle: increased inflammation, enhanced oxidative …

The mechanisms underlying the progression of diabetes mellitus and heart failure are
closely intertwined, such that worsening of one condition is frequently accompanied by …

Sarcopenia is primarily characterized by skeletal muscle disturbances such as loss of
muscle mass, quality, strength, and physical performance. It is commonly seen in elderly …

Non‐alcoholic fatty liver disease (NAFLD) is recognized as the most common type of chronic
liver disease in Western countries and the leading cause of cryptogenic cirrhosis. Insulin …

A breakthrough using “reverse pharmacology” identified and characterized acyl ghrelin from
the stomach as the endogenous cognate ligand for the growth hormone (GH) secretagogue …

Circulating levels of adiponectin (APN) are reduced in obesity and associated comorbidities,
with inflammation playing an important role in downregulating APN production. In contrast to …

Chronic heart failure (CHF) is frequently associated with the involuntary loss of body weight
and muscle wasting, which can determine the course of the disease and its prognosis. While …

Cardiac cachexia (CC) is the clinical entity at the end of the chronic natural course of heart
failure (HF). Despite the efforts, even the most recent definition of cardiac cachexia has been …

Cachexia, a paraneoplastic syndrome markedly associated with worsened prognosis in
cancer patients, provokes profound wasting of both lean and adipose mass in an …