The versatile role of mast cells in allergy, in innate immune responses and in the regulation
of tissue homeostasis is well recognized. However, it is often not made clear that most mast …

Mast cells (MC s) play a central role in tissue homoeostasis, sensing the local environment
through numerous innate cell surface receptors. This enables them to respond rapidly to …

The normal gastrointestinal (GI) mucosa is equipped with mast cells that account for 2–3% of
lamina propria cells under normal conditions. Mast cells are generally associated with …

The NF1 tumor suppressor gene encodes a GTPase-activating protein called neurofibromin
that negatively regulates Ras signaling. Mutations in NF1 cause neurofibromatosis type 1 …

Background and aims: Histamine is known as a regulator of gastrointestinal functions, such
as gastric acid production, intestinal motility, and mucosal ion secretion. Most of this …

The mechanisms underlying stromal cell supportive functions are incompletely understood
but probably implicate a mixture of cytokines, matrix components and cell adhesion …

Our understanding of the relationship between the proatherogenic activities of arterial mast
cells (MCs) and the development of atherosclerotic lesions is advancing. Atherosclerosis is …

The ability of tumor cells to metastasize is associated with a poor prognosis for cancer.
During the process of metastasis, tumor cells circulating in the blood or lymph vessels can …

Metastasis is a key event of malignant tumor progression. The capability to metastasize
depends on the ability of the cancer cell to migrate into connective tissue, adhere, and …

Mast cells have traditionally been considered as effector cells in allergy but during the last
decade it has been realized that mast cells are essentially involved in the mechanisms of …