In contrast to Lewis-acid catalysts, Brønsted acids have been employed primarily as
catalysts for the formation and cleavage of C− O bonds, such as hydrolysis and formation of …

Asymmetric hydroalkoxylation of alkenes constitutes a redox-neutral and 100% atom-
economical strategy toward enantioenriched oxygenated building blocks from readily …

Chiral phosphoric acids (CPAs) have emerged as powerful organocatalysts for asymmetric
reactions, and applications of computational quantum chemistry have revealed important …

Since the groundbreaking reports by the groups of Akiyama and Terada on the use of BINOL-
derived phosphoric acids as organocatalysts, 1, 2 the area of enantioselective Brønsted acid …

Simple feedstock organic molecules, especially alkenes, are attractive starting materials in
organic synthesis because of their wide availability. Direct utilization of such bulk, inert …

Chiral phosphoric acids (CPAs) have been used as efficient organocatalysts since the first
examples were reported 18 years ago by Akiyama and Terada. Although they were …

Synthesis of biologically active molecules (whether at laboratory or industrial scale) remains
a highly appealing area of modern organic chemistry. Nowadays, the need to access …

Free carbene readily causes multiple side reactions due to its high energy, thus its
asymmetric transformation is very difficult. We present here our findings of high‐pKa …

Figure 73: The proposed catalyst/substrate interaction shown in Figure 73 corresponds to
the related sulfoxidation catalyzed by chiral phosphoric acid PA 5 (ref 133). Please note that …

An efficient method for the highly enantioselective synthesis of chiral chromanes bearing
multiple stereogenic centers was developed. A chiral BINOL‐based N‐triflylphosphoramide …