Proteolysis is an irreversible physiological process that can result in the termination or
activation of protein function. Many transmembrane proteins that are involved in the cellular …

Generating inhibitors for AD isintegrin A nd M etalloproteinase 10 (ADAM10), a zinc-
dependent protease, was heavily invested in by the pharmaceutical industry starting over 20 …

Multiple Ras proteins, including N-Ras, depend on a palmitoylation/depalmitoylation cycle to
regulate their subcellular trafficking and oncogenicity. General lipase inhibitors such as …

The synapse is the locus of plasticity where short-term alterations in synaptic strength are
converted to long-lasting memories. In addition to the presynaptic terminal and the …

As a member of the A Disintegrin And Metalloproteinase (ADAM) family, ADAM10 has been
identified as the constitutive α-secretase in the process of amyloid-β protein precursor …

The abnormal accumulation of amyloid-β (Aβ) in the central nervous system is a hallmark of
Alzheimer's disease (AD). The regulation of the processing of the single-transmembrane …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by Aβ-driven
synaptic dysfunction in the early phases of pathogenesis. In the synaptic context, the actin …

ADAM (a disintegrin and metalloproteinase) is a family of widely expressed, transmembrane
and secreted proteins of approximately 750 amino acids in length with functions in cell …

This comprehensive review article dives deep into the Golgi apparatus, an essential
organelle in cellular biology. Beginning with its discovery during the 19th century until …

Alzheimer's disease (AD) represents a global burden in the economics of healthcare
systems. Amyloid-β (Aβ) peptides are formed by amyloid-β precursor protein (AβPP) …