B cells occupy a vital role in the functioning of the immune system, working in tandem with T
cells to either suppress or promote tumor growth within the tumor microenvironment (TME) …

Bruton's tyrosine kinase (BTK) is a key component of B cell receptor (BCR) signalling and
functions as an important regulator of cell proliferation and cell survival in various B cell …

Small-molecule drugs that target the B-cell antigen receptor (BCR) signalosome show
clinical efficacy in the treatment of B-cell non-Hodgkin lymphoma. These agents, including …

Apoptosis, or programmed cell death, is a general mechanism for removal of unwanted cells
from the immune system. It is characterized by chromatin condensation, a reduction in cell …

The integration and control of systemic immune responses depends on the regulated
trafficking of lymphocytes. This lymphocyte “homing” process disperses the immunologic …

Now available in a thoroughly revised Twelfth Edition, Wintrobe's Clinical Hematology
continues to be an industry leader with its ability to correlate basic science with the clinical …

Exosomes are 60–100-nm membrane vesicles that are secreted into the extracellular milieu
as a consequence of multivesicular body fusion with the plasma membrane. Here we …

Integrin-mediated adhesion influences cell survival and may prevent programmed cell
death. Little is known about how drug-sensitive tumor cell lines survive initial exposures to …

After entry into lymph nodes (LNs), B cells migrate to follicles, whereas T cells remain in the
paracortex, with each lymphocyte type showing apparently random migration within these …

The intercellular adhesion molecule (ICAM) 1 is an Ig-like cell adhesion molecule expressed
by several cell types, including leukocytes and endothelial cells. It can be induced in a cell …