Integration of GC–MS and LC–MS for untargeted metabolomics profiling

ÖC Zeki, CC Eylem, T Reçber, S Kır… - Journal of Pharmaceutical …, 2020 - Elsevier
Recently, metabolomics analyses have become increasingly common in the general
scientific community as it is applied in several researches relating to diseases diagnosis …

Cardiovascular metabolomics

RW McGarrah, SB Crown, GF Zhang, SH Shah… - Circulation …, 2018 - Am Heart Assoc
Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics,
one of the newer omics technologies, has emerged as a powerful tool for defining changes …

Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia

Q Zhang, B Riley-Gillis, L Han, Y Jia, A Lodi… - Signal transduction and …, 2022 - nature.com
Despite high initial response rates, acute myeloid leukemia (AML) treated with the BCL-2–
selective inhibitor venetoclax (VEN) alone or in combinations commonly acquires …

Missing value imputation approach for mass spectrometry-based metabolomics data

R Wei, J Wang, M Su, E Jia, S Chen, T Chen, Y Ni - Scientific reports, 2018 - nature.com
Missing values exist widely in mass-spectrometry (MS) based metabolomics data. Various
methods have been applied for handling missing values, but the selection can significantly …

MetaboAnalystR 2.0: from raw spectra to biological insights

J Chong, M Yamamoto, J **a - Metabolites, 2019 - mdpi.com
Global metabolomics based on high-resolution liquid chromatography mass spectrometry
(LC-MS) has been increasingly employed in recent large-scale multi-omics studies …

Machine learning applications for mass spectrometry-based metabolomics

UW Liebal, ANT Phan, M Sudhakar, K Raman… - Metabolites, 2020 - mdpi.com
The metabolome of an organism depends on environmental factors and intracellular
regulation and provides information about the physiological conditions. Metabolomics helps …

metaX: a flexible and comprehensive software for processing metabolomics data

B Wen, Z Mei, C Zeng, S Liu - BMC bioinformatics, 2017 - Springer
Background Non-targeted metabolomics based on mass spectrometry enables high-
throughput profiling of the metabolites in a biological sample. The large amount of data …

Nutrimetabolomics: an integrative action for metabolomic analyses in human nutritional studies

MM Ulaszewska, CH Weinert… - Molecular nutrition & …, 2019 - Wiley Online Library
The life sciences are currently being transformed by an unprecedented wave of
developments in molecular analysis, which include important advances in instrumental …

Use of metabolomics in improving assessment of dietary intake

M Guasch-Ferré, SN Bhupathiraju, FB Hu - Clinical chemistry, 2018 - academic.oup.com
BACKGROUND Nutritional metabolomics is rapidly evolving to integrate nutrition with
complex metabolomics data to discover new biomarkers of nutritional exposure and status …

Analytical opportunities and challenges for data handling with chemometrics strategies from LC-MS based food metabolomics

Z Qin, J Wang, D Wang, H **ao, X Lv, H Chen… - Trends in Food Science & …, 2024 - Elsevier
Background Liquid chromatography-mass spectrometry-based metabolomics allows us to
measure thousands of small metabolites from food matrixes, focused on understanding in …