Can we predict T cell specificity with digital biology and machine learning?

D Hudson, RA Fernandes, M Basham, G Ogg… - Nature Reviews …, 2023 - nature.com
Recent advances in machine learning and experimental biology have offered breakthrough
solutions to problems such as protein structure prediction that were long thought to be …

Current status of immune checkpoint inhibitor immunotherapy for lung cancer

W **ong, Y Zhao, H Du, X Guo - Frontiers in oncology, 2021 - frontiersin.org
Immunotherapy is a major breakthrough in the treatment of cancer in recent years. Immune
checkpoint inhibitors (ICIs) including programmed death-ligand 1 (PD-L1)/programmed …

NCCN guidelines insights: non–small cell lung cancer, version 2.2021: featured updates to the NCCN guidelines

DS Ettinger, DE Wood, DL Aisner, W Akerley… - Journal of the National …, 2021 - jnccn.org
NCCN Guidelines Insights: Non–Small Cell Lung Cancer, Version 2.2021 in: Journal of the
National Comprehensive Cancer Network Volume 19 Issue 3 (2021) Jump to Content User …

Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors

L Zapata, G Caravagna, MJ Williams, E Lakatos… - Nature Genetics, 2023 - nature.com
In cancer, evolutionary forces select for clones that evade the immune system. Here we
analyzed> 10,000 primary tumors and 356 immune-checkpoint-treated metastases using …

Identifying candidates for immunotherapy among patients with non-melanoma skin cancer: a review of the potential predictors of response

E Zelin, CA Maronese, A Dri, L Toffoli, N Di Meo… - Journal of Clinical …, 2022 - mdpi.com
Background: Non-melanoma skin cancer (NMSC) stands as an umbrella term for common
cutaneous malignancies, including basal cell carcinoma (BCC) and cutaneous squamous …

Immune checkpoint inhibitors in triple negative breast cancer: the search for the optimal biomarker

S Qureshi, N Chan, M George, S Ganesan… - Biomarker …, 2022 - journals.sagepub.com
Triple negative breast cancer (TNBC) is a high-risk and aggressive malignancy
characterized by the absence of estrogen receptors (ER) and progesterone receptors (PR) …

Update in immunotherapy for advanced non-small cell lung cancer: optimizing treatment sequencing and identifying the best choices

K Roque, R Ruiz, L Mas, DH Pozza, M Vancini… - Cancers, 2023 - mdpi.com
Simple Summary Immunotherapy stands as a cornerstone in the treatment of advanced lung
cancer patients without an oncogenic driver mutation. This comprehensive review provides …

Plasma proteomic analysis in non-small cell lung cancer patients treated with PD-1/PD-L1 blockade

M Eltahir, J Isaksson, JSM Mattsson, K Kärre, J Botling… - Cancers, 2021 - mdpi.com
Simple Summary Immunotherapy leads to highly variable responses in lung cancer patients.
We assessed the value of a blood-based test to predict which patients would benefit from …

Prognostic and predictive biomarkers in non-small cell lung cancer patients on immunotherapy—The role of liquid biopsy in unraveling the puzzle

E Augustus, K Zwaenepoel, V Siozopoulou, J Raskin… - Cancers, 2021 - mdpi.com
Simple Summary The introduction of immunotherapy modified the cancer treatment
landscape, especially for non-small cell lung cancer (NSCLC). Unfortunately, only a …

Progress on neoadjuvant immunotherapy in resectable non-small cell lung cancer and potential biomarkers

X Wu, YF Chau, H Bai, X Zhuang, J Wang… - Frontiers in …, 2023 - frontiersin.org
Immune checkpoint inhibitors (ICIs) are highly concerned in the treatment of non-small cell
lung cancer (NSCLC), represented by inhibitors of programmed death protein 1 (PD-1) and …