Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

There is more than one way to develop neuronal complexity, and animals frequently use
different molecular toolkits to achieve similar functional outcomes. Genomics and …

Abstract Pannexin 1 (PANX1) is an ATP-permeable channel with critical roles in a variety of
physiological functions such as blood pressure regulation, apoptotic cell clearance and …

Efficient neuronal signaling in the central nervous system strictly depends on a well‐
balanced microenvironment around glial cells, synapses, and axons. Unique features of the …

Over the past several decades a large amount of data have established that glial cells, the
main cell population in the brain, dynamically interact with neurons and thus impact their …

Abstract Pannexin‐1 (Panx1) is a large pore membrane channel with unique conduction
properties ranging from non‐selective ion permeability to the extracellular release of …

Pannexins form channels at the plasma membrane surface that establish a pathway for
communication between the cytosol of individual cells and their extracellular environment …

Probenecid is an old uricosuric agent used in clinics to treat gout and reduce the renal
excretion of antibiotics. In recent years, probenecid has gained attention due to its ability to …

Effective vaccines are slowing the COVID-19 pandemic, but SARS-CoV-2 will likely remain
an issue in the future making it important to have therapeutics to treat patients. There are few …

Astrocytes play a crucial role in the maintenance of the normal functions of the Central
Nervous System (CNS). During the pathogenesis of neurodegenerative diseases, astrocytes …