Quaternary ammonium compounds (QACs) and ionic liquids (ILs) as biocides: From simple antiseptics to tunable antimicrobials

AN Vereshchagin, NA Frolov, KS Egorova… - International journal of …, 2021 - mdpi.com
Quaternary ammonium compounds (QACs) belong to a well-known class of cationic
biocides with a broad spectrum of antimicrobial activity. They are used as essential …

Resistance toward chlorhexidine in oral bacteria–is there cause for concern?

F Cieplik, NS Jakubovics, W Buchalla… - Frontiers in …, 2019 - frontiersin.org
The threat of antibiotic resistance has attracted strong interest during the last two decades,
thus stimulating stewardship programs and research on alternative antimicrobial therapies …

Antibacterial quaternary ammonium agents: Chemical diversity and biological mechanism

W Dan, J Gao, X Qi, J Wang, J Dai - European journal of medicinal …, 2022 - Elsevier
Bacterial infections have seriously threatened public health especially with the increasing
resistance and the cliff-like decline of the number of newly approved antibacterial agents …

The silent pandemic: Emergent antibiotic resistances following the global response to SARS-CoV-2

AR Mahoney, MM Safaee, WM Wuest, AL Furst - Iscience, 2021 - cell.com
The ongoing SARS-CoV-2 pandemic has highlighted the importance of the rapid
development of vaccines and antivirals. However, the potential for the emergence of …

[HTML][HTML] A review of Spaulding's classification system for effective cleaning, disinfection and sterilization of reusable medical devices: Viewed through a modern-day …

NJ Rowan, T Kremer, G McDonnell - Science of the Total Environment, 2023 - Elsevier
Despite advances in medicine and innovations in many underpinning fields including
disease prevention and control, the Spaulding classification system, originally proposed in …

Quaternary ammonium compounds: simple in structure, complex in application

F Bureš - Topics in Current Chemistry, 2019 - Springer
Quaternary ammonium compounds, referred to as QACs, are cationic substances with a
structure on the edge of organic and inorganic chemistry and unique physicochemical …

Design and properties of antimicrobial biomaterials surfaces

B Mehrjou, Y Wu, P Liu, G Wang… - Advanced Healthcare …, 2023 - Wiley Online Library
Emergence of antibiotic‐resistance pathogens has caused serious health issues and if the
current trend is to continue, treatment of the infection will become complicated and even …

Multicationic Quaternary Ammonium Compounds: A Framework for Combating Bacterial Resistance

MA Seferyan, EA Saverina, NA Frolov… - ACS Infectious …, 2023 - ACS Publications
During previous stages of research, high biocidal activity toward microorganism archival
strains has been used as the main indicator in the development of new antiseptic …

Quaternary phosphonium compounds: an examination of non-nitrogenous cationic amphiphiles that evade disinfectant resistance

KJ Sommers, ME Michaud, CE Hogue… - ACS infectious …, 2022 - ACS Publications
Quaternary ammonium compounds (QACs) serve as mainstays in the formulation of
disinfectants and antiseptics. However, an over-reliance and misuse of our limited QAC …

More QACs, more questions: Recent advances in structure activity relationships and hurdles in understanding resistance mechanisms

KR Morrison, RA Allen, KPC Minbiole, WM Wuest - Tetrahedron letters, 2019 - Elsevier
Quaternary ammonium compounds (QACs) are a class of antimicrobials that have been
around for over a century; nevertheless, they have found continued renewal in the structures …