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The genetic basis of major depression
Major depressive disorder (MDD) is a common, debilitating, phenotypically heterogeneous
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …
Circadian depression: a mood disorder phenotype
Major mood syndromes are among the most common and disabling mental disorders.
However, a lack of clear delineation of their underlying pathophysiological mechanisms is a …
However, a lack of clear delineation of their underlying pathophysiological mechanisms is a …
Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction
Despite an estimated heritability of~ 50%, genome-wide association studies of opioid use
disorder (OUD) have revealed few genome-wide significant loci. We conducted a cross …
disorder (OUD) have revealed few genome-wide significant loci. We conducted a cross …
Role of the gut-brain axis in the shared genetic etiology between gastrointestinal tract diseases and psychiatric disorders: a genome-wide pleiotropic analysis
Importance Comorbidities and genetic correlations between gastrointestinal tract diseases
and psychiatric disorders have been widely reported, with the gut-brain axis (GBA) …
and psychiatric disorders have been widely reported, with the gut-brain axis (GBA) …
The genetics of the mood disorder spectrum: genome-wide association analyses of more than 185,000 cases and 439,000 controls
Background Mood disorders (including major depressive disorder and bipolar disorder)
affect 10% to 20% of the population. They range from brief, mild episodes to severe …
affect 10% to 20% of the population. They range from brief, mild episodes to severe …
A powerful method for pleiotropic analysis under composite null hypothesis identifies novel shared loci between Type 2 Diabetes and Prostate Cancer
There is increasing evidence that pleiotropy, the association of multiple traits with the same
genetic variants/loci, is a very common phenomenon. Cross-phenotype association tests are …
genetic variants/loci, is a very common phenomenon. Cross-phenotype association tests are …
The genetics of depression: successful genome-wide association studies introduce new challenges
The recent successful genome-wide association studies (GWASs) for depression have
yielded more than 80 replicated loci and brought back the excitement that had evaporated …
yielded more than 80 replicated loci and brought back the excitement that had evaporated …
[HTML][HTML] Genetic associations between voltage-gated calcium channels and psychiatric disorders
Psychiatric disorders are mental, behavioral or emotional disorders. These conditions are
prevalent, one in four adults suffer from any type of psychiatric disorders world-wide. It has …
prevalent, one in four adults suffer from any type of psychiatric disorders world-wide. It has …
A sex-specific genome-wide association study of depression phenotypes in UK Biobank
There are marked sex differences in the prevalence, phenotypic presentation and treatment
response for major depression. While genome-wide association studies (GWAS) adjust for …
response for major depression. While genome-wide association studies (GWAS) adjust for …
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder
Lithium is a first-line medication for bipolar disorder (BD), but only one in three patients
respond optimally to the drug. Since evidence shows a strong clinical and genetic overlap …
respond optimally to the drug. Since evidence shows a strong clinical and genetic overlap …