In most daily activities related to work or leisure, the energy for muscle work substantially
comes from oxidative metabolism. Functional limitations or impairments of this metabolism …

The recent developments in time-domain diffuse optics that rely on physical concepts (eg,
time-gating and null distance) and advanced photonic components (eg, vertical cavity …

Light is a powerful tool to non-invasively probe highly scattering media for clinical
applications ranging from oncology to neurology, but also for molecular imaging, and quality …

Significance: Multi-laboratory initiatives are essential in performance assessment and
standardization—crucial for bringing biophotonics to mature clinical use—to establish …

Time-domain measurements facilitate the elimination of the influence of extracerebral,
systemic effects, a key problem in functional near-infrared spectroscopy (fNIRS) of the adult …

Time-domain diffuse optics is a powerful non-invasive, non-ionizing and label-free
technique based on the use of picosecond pulsed laser light to probe highly scattering …

This work reviews physical concepts, technologies and applications of time-domain diffuse
optics based on time-gated single-photon detection. This particular photon detection …

Diffuse optical spectroscopy (DOS) and diffuse optical imaging (DOI) are emerging non-
invasive imaging modalities that have wide spread potential applications in many fields …

Significance Interstitial fiber-based spectroscopy is gaining interest for real-time in vivo
optical biopsies, endoscopic interventions, and local monitoring of therapy. Different from …

The adoption of a short source-detector distance, combined with a time-resolved acquisition,
can be advantageous in diffuse optical imaging due to the stricter spatial localization of the …