Biomarker discovery and implementation are at the forefront of the precision medicine
movement. Modern advances in the field of metabolomics afford the opportunity to readily …

This article is one of ten reviews selected from the Annual Update in Intensive Care and
Emergency Medicine 2019. Other selected articles can be found online at https://www …

Exercise intolerance is a major manifestation of post-acute sequelae of severe acute
respiratory syndrome coronavirus infection (PASC, or “long-COVID”). Exercise intolerance in …

The pandemic of the coronavirus disease 2019 (COVID-19) has become a global public
health crisis. The symptoms of COVID-19 range from mild to severe, but the physiological …

Data mining involves the use of mathematical sciences, statistics, artificial intelligence, and
machine learning to determine the relationships between variables from a large sample of …

Sepsis is characterized by complex pathophysiology and heterogeneous phenotypes of
affected patients regarding their symptoms, response to treatment, and outcomes. At present …

Background Sepsis is a leading cause of death in intensive care units (ICUs), but outcomes
of individual patients are difficult to predict. The recently developed clinical metabolomics …

A comprehensive understanding of host dependency factors for SARS-CoV-2 remains
elusive. Here, we map alterations in host lipids following SARS-CoV-2 infection using …

Sepsis is a serious medical condition that occurs in 30% of patients in intensive care units
(ICUs). Early detection of sepsis is key to prevent its progression to severe sepsis and septic …

Bioenergetic failure caused by impaired utilisation of glucose and fatty acids contributes to
organ dysfunction across multiple tissues in critical illness. Ketone bodies may form an …