Soft connective tissues at steady state are dynamic; resident cells continually read
environmental cues and respond to them to promote homeostasis, including maintenance of …

Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …

Biological structures span many orders of magnitude in size, but far-field visible light
microscopy suffers from limited resolution. A new method for fluorescence imaging has been …

Cell migration affects all morphogenetic processes and contributes to numerous diseases,
including cancer and cardiovascular disease. For most cells in most environments …

Recent progress in the design and application of artificial cellular microenvironments and
nanoenvironments has revealed the extraordinary ability of cells to adjust their cytoskeletal …

Non-muscle myosin II (NM II) is an actin-binding protein that has actin cross-linking and
contractile properties and is regulated by the phosphorylation of its light and heavy chains …

Actin filaments assemble into diverse protrusive and contractile structures to provide force
for a number of vital cellular processes. Stress fibers are contractile actomyosin bundles …

Recent advances in far-field optical nanoscopy have enabled fluorescence imaging with a
spatial resolution of 20 to 50 nanometers. Multicolor super-resolution imaging, however …

Cell migration requires sustained forward movement of the plasma membrane at the cell's
front or" leading edge." To date, researchers have uncovered four distinct ways of extending …

During cell migration, the forces generated in the actin cytoskeleton are transmitted across
transmembrane receptors to the extracellular matrix or other cells through a series of …