Toxicity testing in the 21st century: progress in the past decade and future perspectives
D Krewski, ME Andersen, MG Tyshenko… - Archives of …, 2020 - Springer
Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …
based on expanded application of high-throughput in vitro screening and in silico methods …
In vitro to in vivo extrapolation for high throughput prioritization and decision making
In vitro chemical safety testing methods offer the potential for efficient and economical tools
to provide relevant assessments of human health risk. To realize this potential, methods are …
to provide relevant assessments of human health risk. To realize this potential, methods are …
The CompTox Chemistry Dashboard: a community data resource for environmental chemistry
Despite an abundance of online databases providing access to chemical data, there is
increasing demand for high-quality, structure-curated, open data to meet the various needs …
increasing demand for high-quality, structure-curated, open data to meet the various needs …
The next generation blueprint of computational toxicology at the US Environmental Protection Agency
Abstract The US Environmental Protection Agency (EPA) is faced with the challenge of
efficiently and credibly evaluating chemical safety often with limited or no available toxicity …
efficiently and credibly evaluating chemical safety often with limited or no available toxicity …
Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization
Use of high-throughput, in vitro bioactivity data in setting a point-of-departure (POD) has the
potential to accelerate the pace of human health safety evaluation by informing screening …
potential to accelerate the pace of human health safety evaluation by informing screening …
Integrating tools for non-targeted analysis research and chemical safety evaluations at the US EPA
Tens-of-thousands of chemicals are registered in the US for use in countless processes and
products. Recent evidence suggests that many of these chemicals are measureable in …
products. Recent evidence suggests that many of these chemicals are measureable in …
[HTML][HTML] Evaluating consumer exposure to disinfecting chemicals against coronavirus disease 2019 (COVID-19) and associated health risks
Disinfection of surfaces has been recommended as one of the most effective ways to combat
the spread of novel coronavirus (SARS-CoV-2) that causes coronavirus disease 2019 …
the spread of novel coronavirus (SARS-CoV-2) that causes coronavirus disease 2019 …
[HTML][HTML] Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models
Nominal effect concentrations from in vitro toxicity assays may lead to inaccurate estimations
of in vivo toxic doses because the nominal concentration poorly reflects the concentration at …
of in vivo toxic doses because the nominal concentration poorly reflects the concentration at …
IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making
X Chang, YM Tan, DG Allen, S Bell, PC Brown… - Toxics, 2022 - mdpi.com
During the past few decades, the science of toxicology has been undergoing a
transformation from observational to predictive science. New approach methodologies …
transformation from observational to predictive science. New approach methodologies …
Building and applying quantitative adverse outcome pathway models for chemical hazard and risk assessment
An important goal in toxicology is the development of new ways to increase the speed,
accuracy, and applicability of chemical hazard and risk assessment approaches. A …
accuracy, and applicability of chemical hazard and risk assessment approaches. A …