Functionalizing DNA origami to investigate and interact with biological systems

GA Knappe, EC Wamhoff, M Bathe - Nature Reviews Materials, 2023 - nature.com
DNA origami has emerged as a powerful method to generate DNA nanostructures with
dynamic properties and nanoscale control. These nanostructures enable complex …

Functionalizing framework nucleic‐acid‐based nanostructures for biomedical application

T Zhang, T Tian, Y Lin - Advanced Materials, 2022 - Wiley Online Library
Strategies for functionalizing diverse tetrahedral framework nucleic acids (tFNAs) have been
extensively explored since the first successful fabrication of tFNA by Turberfield. One‐pot …

Thermal‐responsive MXene‐DNA hydrogel for near‐infrared light triggered localized photothermal‐chemo synergistic cancer therapy

PP He, X Du, Y Cheng, Q Gao, C Liu, X Wang, Y Wei… - Small, 2022 - Wiley Online Library
Stimuli‐responsive DNA hydrogels are promising candidates for cancer treatment, as they
not only possess biocompatible and biodegradable 3D network structures as highly efficient …

DNA origami: from molecular folding art to drug delivery technology

Q Jiang, Y Shang, Y **e, B Ding - Advanced Materials, 2024 - Wiley Online Library
DNA molecules that store genetic information in living creatures can be repurposed as
building blocks to construct artificial architectures, ranging from the nanoscale to the …

Enhanced postsurgical cancer treatment using methacrylated glycol chitosan hydrogel for sustained DNA/doxorubicin delivery and immunotherapy

HS Seo, JH Han, J Lim, GH Bae, MJ Byun… - Biomaterials …, 2024 - spj.science.org
Background: Cancer recurrence and metastasis are major contributors to treatment failure
following tumor resection surgery. We developed a novel implantable drug delivery system …

[HTML][HTML] Rhabdomyosarcoma: current therapy, challenges, and future approaches to treatment strategies

A Zarrabi, D Perrin, M Kavoosi, M Sommer, S Sezen… - Cancers, 2023 - mdpi.com
Simple Summary Rhabdomyosarcoma (RMS) is a rare pediatric sarcoma affecting skeletal
muscle in children and young adults. It is responsible for 3% of all childhood malignant …

Designer DNA nanostructures for therapeutics

S Jiang, Z Ge, S Mou, H Yan, C Fan - Chem, 2021 - cell.com
The field of structural DNA nanotechnology applies the programmability of Watson-Crick
base pairing to the construction of custom nanostructures that are prescribed by the …

DNA Framework‐Enabled 3D Organization of Antiarrhythmic Drugs for Radiofrequency Catheter Ablation

H Chen, F Li, Y Ge, J Liu, X **ng, M Li, Z Ge… - Advanced …, 2024 - Wiley Online Library
Preorganizing molecular drugs within a microenvironment is crucial for the development of
efficient and controllable therapeutic systems. Here, the use of tetrahedral DNA framework …

DNA-origami-directed virus capsid polymorphism

I Seitz, S Saarinen, EP Kumpula, D McNeale… - Nature …, 2023 - nature.com
Viral capsids can adopt various geometries, most iconically characterized by icosahedral or
helical symmetries. Importantly, precise control over the size and shape of virus capsids …

[HTML][HTML] Aptamer-enabled nanomaterials for therapeutics, drug targeting and imaging

M Liu, L Wang, Y Lo, SCC Shiu, AB Kinghorn… - Cells, 2022 - mdpi.com
A wide variety of nanomaterials have emerged in recent years with advantageous properties
for a plethora of therapeutic and diagnostic applications. Such applications include drug …