Proteins, which have inherent biorecognition properties, have long been used as
therapeutic agents for the treatment of a wide variety of clinical indications. Protein …

Covalent attachment of poly (ethylene) glycol (PEG) groups to proteins, a process commonly
called PEGylation, is often used to improve the performance of a protein in vivo. To date, at …

The retention and binding mechanisms in electrostatic interaction‐based chromatography
(ion‐exchange chromatography) of PEGylated proteins (covalent attachment of polyethylene …

The chromatographic methods used for the purification of PEGylated proteins are mainly
Size Exclusion (SEC) and Ion Exchange Chromatography (IEX). Although the PEGylation …

BACKGROUND: PEGylation reactions often result in a heterogeneous population of
conjugated species and unmodified proteins that presents a protein separations challenge …

Laccase is a multicopper oxidase that catalyzes the oxidation of phenolic compounds.
Laccase can be used in bioremediation, beverage (wine, fruit juice, and beer) processing …

Adsorption of native as well as mono-, di-, and tri-PEGylated lysozyme on Toyopearl
Gigacap S-650M in sodium phosphate buffer is studied by isothermal titration calorimetry …

Background PEGylation, defined as the covalent attachment of polyethylene glycol, allows
the synthesis of PEGylated therapeutic proteins with enhanced physicochemical properties …

Covalent grafting of poly (ethylene glycol) chains to proteins (“PEGylation”) is emerging as
an effective technique to increase the in vivo circulation time and efficacy of protein drugs …

Adsorption of native as well as mono-, di-, and tri-PEGylated lysozyme on Toyopearl PPG-
600M, a mildly hydrophobic resin is studied by isothermal titration calorimetry and by …