Polycystic ovary syndrome (PCOS) is a disease in which endocrine metabolic abnormalities
coexist with reproductive system abnormalities, with the main clinical manifestations …

Intestinal absorption of food is one of the sources of glucose. Insulin resistance and impaired
glucose tolerance caused by lifestyle and diet are the precursors of type 2 diabetes. Patients …

Insulin resistance (IR) is the primary pathological mechanism underlying type 2 diabetes
mellitus (T2DM). Here, the study aimed to ascertain whether and how exercise mediates IR …

Pancreatic beta cells secrete insulin in response to stimulation with glucose and other
nutrients, and impaired insulin secretion plays a central role in development of diabetes …

Islets of Langerhans are multicellular microorgans located in the pancreas that play a central
role in whole-body energy homeostasis. Through secretion of insulin and other hormones …

Abstract Objective Type 2 diabetes (T2D) is characterised by the loss of first-phase insulin
secretion. We studied mice with β-cell selective loss of the glucagon receptor (Gcgr fl/fl X Ins …

Many details of glucose-stimulated intracellular calcium changes in β cells during activation,
activity, and deactivation, as well as their concentration-dependence, remain to be analyzed …

NMDA receptors promote repolarization in pancreatic beta cells and thereby reduce glucose-
stimulated insulin secretion. Therefore, NMDA receptors are a potential therapeutic target for …

Mouse models of diet-induced type 2 diabetes mellitus provide powerful tools for studying
the structural and physiological changes that are related to the disease progression. In this …

Self-organized critical dynamics is assumed to be an attractive mode of functioning for
several real-life systems and entails an emergent activity in which the extent of observables …