Small cell lung cancer (SCLC) is characterized by morphologic, epigenetic and
transcriptomic heterogeneity. Subtypes based upon predominant transcription factor …

The use of liquid biopsies for cancer detection and management is rapidly gaining
prominence. Current methods for the detection of circulating tumour DNA involve …

DNA methylation, the reversible addition of methyl groups at CpG dinucleotides, represents
an important regulatory layer associated with gene expression. Changed methylation status …

Liquid biopsy based on cell-free DNA (cfDNA) enables non-invasive dynamic assessment of
disease status in patients with cancer, both in the early and advanced settings. The analysis …

Improving early cancer detection has the potential to substantially reduce cancer-related
mortality. Cell-free methylated DNA immunoprecipitation and high-throughput sequencing …

In mammalian cells, DNA methylation on the fifth position of cytosine (5mC) plays an
important role as an epigenetic mark. However, DNA methylation was considered to be …

RnBeads is a software tool for large-scale analysis and interpretation of DNA methylation
data, providing a user-friendly analysis workflow that yields detailed hypertext reports …

Ancestral environmental exposures to a variety of factors and toxicants have been shown to
promote the epigenetic transgenerational inheritance of adult onset disease. One of the …

The ability to form memories is a prerequisite for an organism's behavioral adaptation to
environmental changes. At the molecular level, the acquisition and maintenance of memory …

As hippocampal neurons respond to diverse types of information, a subset assembles into
microcircuits representing a memory. Those neurons typically undergo energy-intensive …