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Antimicrobial resistance in rivers: a review of the genes detected and new challenges
River ecosystems are very important parts of the water cycle and an excellent habitat, food,
and drinking water source for many organisms, including humans. Antibiotics are emerging …
and drinking water source for many organisms, including humans. Antibiotics are emerging …
[HTML][HTML] Consequences of genomic diversity in Mycobacterium tuberculosis
The causative agent of human tuberculosis, Mycobacterium tuberculosis complex (MTBC),
comprises seven phylogenetically distinct lineages associated with different geographical …
comprises seven phylogenetically distinct lineages associated with different geographical …
Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study
Background Diagnosing drug-resistance remains an obstacle to the elimination of
tuberculosis. Phenotypic drug-susceptibility testing is slow and expensive, and commercial …
tuberculosis. Phenotypic drug-susceptibility testing is slow and expensive, and commercial …
Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
Generalist and specialist species differ in the breadth of their ecological niches. Little is
known about the niche width of obligate human pathogens. Here we analyzed a global …
known about the niche width of obligate human pathogens. Here we analyzed a global …
A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region
The human-and animal-adapted lineages of the Mycobacterium tuberculosis complex
(MTBC) are thought to have expanded from a common progenitor in Africa. However, the …
(MTBC) are thought to have expanded from a common progenitor in Africa. However, the …
Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis
The rise of antibiotic-resistant bacteria has led to an urgent need for rapid detection of drug
resistance in clinical samples, and improvements in global surveillance. Here we show how …
resistance in clinical samples, and improvements in global surveillance. Here we show how …
Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences
Mycobacterium tuberculosis drug resistance (DR) challenges effective tuberculosis disease
control. Current molecular tests examine limited numbers of mutations, and although whole …
control. Current molecular tests examine limited numbers of mutations, and although whole …
Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues
Whole genome sequencing (WGS) of Mycobacterium tuberculosis has rapidly progressed
from a research tool to a clinical application for the diagnosis and management of …
from a research tool to a clinical application for the diagnosis and management of …
MTBseq: a comprehensive pipeline for whole genome sequence analysis of Mycobacterium tuberculosis complex isolates
TA Kohl, C Utpatel, V Schleusener, MR De Filippo… - PeerJ, 2018 - peerj.com
Analyzing whole-genome sequencing data of Mycobacterium tuberculosis complex (MTBC)
isolates in a standardized workflow enables both comprehensive antibiotic resistance …
isolates in a standardized workflow enables both comprehensive antibiotic resistance …
Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe
Two billion people are infected with Mycobacterium tuberculosis, leading to 10 million new
cases of active tuberculosis and 1.5 million deaths annually. Universal access to drug …
cases of active tuberculosis and 1.5 million deaths annually. Universal access to drug …