Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-
permeable component of excitatory neurotransmission in the central nervous system (CNS) …

▪ Abstract Spines are neuronal protrusions, each of which receives input typically from one
excitatory synapse. They contain neurotransmitter receptors, organelles, and signaling …

Abstract N-methyl-D-aspartate (NMDA) receptors mediate excitatory neurotransmission in
the mammalian brain. Two glycine-binding NR1 subunits and two glutamate-binding NR2 …

Objective Early‐onset epileptic encephalopathies have been associated with de novo
mutations of numerous ion channel genes. We employed techniques of modern translational …

Most neuroprotective drugs have failed in clinical trials because of side‐effects, causing
normal brain function to become compromised. A case in point concerns antagonists of the …

The changes in synaptic morphology and receptor content that underlie neural plasticity are
poorly understood. Here, we use a pH-sensitive green fluorescent protein to tag …

NMDA-type glutamate receptors are ligand-gated ion channels that mediate a major
component of excitatory neurotransmission in the central nervous system (CNS). They are …

N-methyl-d-aspartate receptors (NMDARs) are ligand-gated ion channels
('ionotropic'receptors) activated by the major excitatory neurotransmitter, l-glutamate. While …

Physiological body temperature is an important determinant for neural functions, and it is
well established that changes in temperature have dynamic influences on hippocampal …