Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies
J Zhang, Y Zhang, J Wang, Y **a, J Zhang… - Signal transduction and …, 2024 - nature.com
Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …
Understanding the neuronal synapse and challenges associated with the mitochondrial dysfunction in mild cognitive impairment and Alzheimer's disease
H Verma, P Gangwar, A Yadav, B Yadav, R Rao… - Mitochondrion, 2023 - Elsevier
Synaptic mitochondria are crucial for maintaining synaptic activity due to their high energy
requirements, substantial calcium (Ca 2+) fluctuation, and neurotransmitter release at the …
requirements, substantial calcium (Ca 2+) fluctuation, and neurotransmitter release at the …
An in-silico investigation based on molecular simulations of novel and potential brain-penetrant GluN2B NMDA receptor antagonists as anti-stroke therapeutic agents
GluN2B-induced activation of NMDA receptors plays a key function in central nervous
system (CNS) disorders, including Parkinson, Alzheimer, and stroke, as it is strongly …
system (CNS) disorders, including Parkinson, Alzheimer, and stroke, as it is strongly …
[HTML][HTML] P-coumaric acid ameliorates Aβ25–35-induced brain damage in mice by modulating gut microbiota and serum metabolites
B Cao, M Zeng, F Hao, Z Hao, Z Zhang, X Liang… - Biomedicine & …, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease for which there is a
lack of effective therapeutic drugs. There is great potential for natural products to be used in …
lack of effective therapeutic drugs. There is great potential for natural products to be used in …
[HTML][HTML] Targeting autophagy in Alzheimer's disease: Animal models and mechanisms
XW Zhang, XX Zhu, DS Tang, JH Lu - Zoological research, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is an age-related progressive neurodegenerative disorder that
leads to cognitive impairment and memory loss. Emerging evidence suggests that …
leads to cognitive impairment and memory loss. Emerging evidence suggests that …
[HTML][HTML] Exploring the therapeutic potential of natural compounds for Alzheimer's disease: mechanisms of action and pharmacological properties
J Liu, T Li, G Zhong, Y Pan, M Gao, S Su… - Biomedicine & …, 2023 - Elsevier
Alzheimer's Disease (AD) is a global public health priority characterized by high mortality
rates in adults and an increasing prevalence in aging populations worldwide. Despite …
rates in adults and an increasing prevalence in aging populations worldwide. Despite …
Discovery of New Highly Potent Histamine H3 Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors
At present, one of the most promising strategies to tackle the complex challenges posed by
Alzheimer's disease (AD) involves the development of novel multitarget-directed ligands …
Alzheimer's disease (AD) involves the development of novel multitarget-directed ligands …
Biological activities of Hypericum spectabile extract optimized using artificial neural network combined with genetic algorithm application
Optimizing extraction conditions can help maximize the efficiency and yield of the extraction
process while minimizing negative impacts on the environment and human health. For the …
process while minimizing negative impacts on the environment and human health. For the …
Design, synthesis, and biological evaluation of imidazolylacetophenone oxime derivatives as novel brain-penetrant agents for Alzheimer's disease treatment
ZY Bian, PX Li, XY Feng, YR Zhou, FY Cheng… - European Journal of …, 2024 - Elsevier
Alzheimer's disease (AD, also known as dementia) has become a serious global health
problem along with population aging, and neuroinflammation is the underlying cause of …
problem along with population aging, and neuroinflammation is the underlying cause of …
[HTML][HTML] Glutamate: Molecular Mechanisms and Signaling Pathway in Alzheimer's Disease, a Potential Therapeutic Target
N Puranik, M Song - Molecules, 2024 - mdpi.com
Gamma-glutamate is an important excitatory neurotransmitter in the central nervous system
(CNS), which plays an important role in transmitting synapses, plasticity, and other brain …
(CNS), which plays an important role in transmitting synapses, plasticity, and other brain …