Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies

J Zhang, Y Zhang, J Wang, Y **a, J Zhang… - Signal transduction and …, 2024 - nature.com
Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …

Understanding the neuronal synapse and challenges associated with the mitochondrial dysfunction in mild cognitive impairment and Alzheimer's disease

H Verma, P Gangwar, A Yadav, B Yadav, R Rao… - Mitochondrion, 2023 - Elsevier
Synaptic mitochondria are crucial for maintaining synaptic activity due to their high energy
requirements, substantial calcium (Ca 2+) fluctuation, and neurotransmitter release at the …

An in-silico investigation based on molecular simulations of novel and potential brain-penetrant GluN2B NMDA receptor antagonists as anti-stroke therapeutic agents

M El Fadili, M Er-Rajy, W Ali Eltayb, M Kara… - Journal of …, 2024 - Taylor & Francis
GluN2B-induced activation of NMDA receptors plays a key function in central nervous
system (CNS) disorders, including Parkinson, Alzheimer, and stroke, as it is strongly …

[HTML][HTML] P-coumaric acid ameliorates Aβ25–35-induced brain damage in mice by modulating gut microbiota and serum metabolites

B Cao, M Zeng, F Hao, Z Hao, Z Zhang, X Liang… - Biomedicine & …, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease for which there is a
lack of effective therapeutic drugs. There is great potential for natural products to be used in …

[HTML][HTML] Targeting autophagy in Alzheimer's disease: Animal models and mechanisms

XW Zhang, XX Zhu, DS Tang, JH Lu - Zoological research, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is an age-related progressive neurodegenerative disorder that
leads to cognitive impairment and memory loss. Emerging evidence suggests that …

[HTML][HTML] Exploring the therapeutic potential of natural compounds for Alzheimer's disease: mechanisms of action and pharmacological properties

J Liu, T Li, G Zhong, Y Pan, M Gao, S Su… - Biomedicine & …, 2023 - Elsevier
Alzheimer's Disease (AD) is a global public health priority characterized by high mortality
rates in adults and an increasing prevalence in aging populations worldwide. Despite …

Discovery of New Highly Potent Histamine H3 Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors

R Malek, K Sałat, P Totoson, T Karcz… - ACS Chemical …, 2024 - ACS Publications
At present, one of the most promising strategies to tackle the complex challenges posed by
Alzheimer's disease (AD) involves the development of novel multitarget-directed ligands …

Biological activities of Hypericum spectabile extract optimized using artificial neural network combined with genetic algorithm application

A Gürgen, M Sevindik, T Krupodorova, I Uysal… - BMC biotechnology, 2024 - Springer
Optimizing extraction conditions can help maximize the efficiency and yield of the extraction
process while minimizing negative impacts on the environment and human health. For the …

Design, synthesis, and biological evaluation of imidazolylacetophenone oxime derivatives as novel brain-penetrant agents for Alzheimer's disease treatment

ZY Bian, PX Li, XY Feng, YR Zhou, FY Cheng… - European Journal of …, 2024 - Elsevier
Alzheimer's disease (AD, also known as dementia) has become a serious global health
problem along with population aging, and neuroinflammation is the underlying cause of …

[HTML][HTML] Glutamate: Molecular Mechanisms and Signaling Pathway in Alzheimer's Disease, a Potential Therapeutic Target

N Puranik, M Song - Molecules, 2024 - mdpi.com
Gamma-glutamate is an important excitatory neurotransmitter in the central nervous system
(CNS), which plays an important role in transmitting synapses, plasticity, and other brain …