COVID-19 and bone loss: a review of risk factors, mechanisms, and future directions

A Creecy, OD Awosanya, A Harris, X Qiao… - Current Osteoporosis …, 2024 - Springer
Abstract Purpose of Review SARS-CoV-2 drove the catastrophic global phenomenon of the
COVID-19 pandemic resulting in a multitude of systemic health issues, including bone loss …

SARS-CoV-2 and its multifaceted impact on bone health: mechanisms and clinical evidence

A Harris, A Creecy, OD Awosanya, T McCune… - Current Osteoporosis …, 2024 - Springer
Abstract Purpose of Review SARS-CoV-2 infection, the culprit of the COVID-19 pandemic,
has been associated with significant long-term effects on various organ systems, including …

Blockade of endothelin receptors mitigates SARS-CoV-2-induced osteoarthritis

MT Au, J Ni, K Tang, W Wang, L Zhang, H Wang… - Nature …, 2024 - nature.com
Joint pain and osteoarthritis can occur as coronavirus disease 2019 (COVID-19) sequelae
after infection. However, little is known about the damage to articular cartilage. Here we …

Serum proinflammatory cytokines, receptor activator of nuclear factor kappa-Β ligand (RANKL), osteoprotegerin (OPG) and RANKL/OPG ratio in mild and severe …

S Kazemi-Sufi, S Alipour, M Rabieepour… - BMC Infectious …, 2024 - Springer
Introduction Osteoporosis, a systemic skeletal disease, is characterized by a quantitative
and qualitative, and progressive decrease in bone mass, which is related to inflammation …

Dietary vitamin D mitigates Coronavirus-Induced Lung inflammation and damage in mice

G Campolina-Silva, ACSP Andrade, M Couto… - Viruses, 2023 - mdpi.com
The COVID-19 pandemic caused by the SARS-CoV-2 (β-CoV) betacoronavirus has posed a
significant threat to global health. Despite the availability of vaccines, the virus continues to …

In-silico analysis predicts disruption of normal angiogenesis as a causative factor in osteoporosis pathogenesis

R James, KN Subramanyam, F Payva, AP E, VK TV… - BMC Genomic …, 2024 - Springer
Angiogenesis-osteogenesis coupling is critical for proper functioning and maintaining the
health of bones. Any disruption in this coupling, associated with aging and disease, might …

[HTML][HTML] Bone Mineral Density, Bone Biomarkers, and Joints in Acute, Post, and Long COVID-19: A Systematic Review

F Alghamdi, K Mokbel, R Meertens, AD Obotiba… - Viruses, 2024 - mdpi.com
SARS-CoV-2 is highly transmissible and affects the respiratory system. People with COVID-
19 are at higher risk of physical and mental health conditions, which could impact bone …

The abortive SARS‐CoV‐2 infection of osteoclast precursors promotes their differentiation into osteoclasts

F Sviercz, P Jarmoluk, J Godoy Coto… - Journal of Medical …, 2024 - Wiley Online Library
Abstract The Coronavirus Disease 2019 (COVID‐19) pandemic has resulted in the loss of
millions of lives, although a majority of those infected have managed to survive …

OPG and BAFF as predictive biomarkers of the severity of SARS‐CoV‐2 infection

A Ruiz, C Peña‐Bates, LA Ramon‐Luing… - Journal of Cellular …, 2025 - Wiley Online Library
Molecules of the tumour necrosis factor superfamily (TNFSF) are key players in immune
regulation; an increase in some TNFSF molecules has been reported during severe COVID …

[HTML][HTML] E3 Ubiquitin Ligase Smurf1 Regulates the Inflammatory Response in Macrophages and Attenuates Hepatic Damage during Betacoronavirus Infection

LP Souza-Costa, FRS Santos, JC Pimenta… - Pathogens, 2024 - mdpi.com
The E3 ubiquitin ligase Smurf1 catalyzes the ubiquitination and proteasomal degradation of
several protein substrates related to inflammatory responses and antiviral signaling. This …