Recent progress in nitric oxide-generating nanomedicine for cancer therapy

Y Li, B Yoon, A Dey, JH Park - Journal of Controlled Release, 2022‏ - Elsevier
Nitric oxide (NO) is an endogenous, multipotent biological signaling molecule that
participates in several physiological processes. Recently, exogenous supplementation of …

Engineering macromolecular nanocarriers for local delivery of gaseous signaling molecules

J Hu, Y Fang, X Huang, R Qiao, JF Quinn… - Advanced Drug Delivery …, 2021‏ - Elsevier
In addition to being notorious air pollutants, nitric oxide (NO), carbon monoxide (CO), and
hydrogen sulfide (H 2 S) have also been known as endogenous gaseous signaling …

Recent Advancements in Polymeric N-Nitrosamine-Based Nitric Oxide (NO) Donors and their Therapeutic Applications

A Mondal, S Paul, P De - Biomacromolecules, 2024‏ - ACS Publications
Nitric oxide (NO), a gasotransmitter, is known for its wide range of effects in vasodilation,
cardiac relaxation, and angiogenesis. This diatomic free radical also plays a pivotal role in …

Nitric oxide (NO)-releasing macromolecules: rational design and biomedical applications

J Cheng, K He, Z Shen, G Zhang, Y Yu, J Hu - Frontiers in chemistry, 2019‏ - frontiersin.org
Nitric oxide (NO) has been recognized as a ubiquitous gaseous transmitter and the
therapeutic potential has nowadays received increasing interest. However, NO cannot be …

Advances in the synthesis of non-annelated polynuclear heterocyclic systems comprising the 1, 2, 5-oxadiazole ring

LL Fershtat, NN Makhova - Russian Chemical Reviews, 2016‏ - iopscience.iop.org
This review is concerned with recently developed synthetic methods for non-annelated
polynuclear heterocyclic systems that incorporate, along with a furazan and (or) furoxan ring …

Recent advance in self‐assembled polymeric nanomedicines for gaseous signaling molecule delivery

AJ van der Vlies, S Yamane… - Wiley Interdisciplinary …, 2024‏ - Wiley Online Library
Gaseous signaling molecules such as nitric oxide (NO), carbon monoxide (CO), and
hydrogen sulfide (H2S) have recently been recognized as essential signal mediators that …

Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing

D **a, Y Guo, R Xu, N Li - Journal of Nanobiotechnology, 2025‏ - Springer
The challenges associated with prolonged healing or non-healing of chronic diabetic
wounds contribute significantly to the increased incidence of lower limb amputation. A …

Recent advances in macromolecular prodrugs

CF Riber, AN Zelikin - Current Opinion in Colloid & Interface Science, 2017‏ - Elsevier
Macromolecular prodrugs (MP) are high molar mass conjugates, typically carrying several
copies of a drug or a drug combination, designed to optimize delivery of the drug, that is—its …

Enhanced Nitric Oxide Delivery Through Self‐Assembling Nanoparticles for Eradicating Gram‐Negative Bacteria

X Lai, L Yu, X Huang, W Gardner… - Advanced …, 2024‏ - Wiley Online Library
In the current battle against antibiotic resistance, the resilience of Gram‐negative bacteria
against traditional antibiotics is due not only to their protective outer membranes but also to …

Highlighting the Underrated Side of the High Profile Nitroso Entity as a Nucleophile

GN Pairas, PG Tsoungas - ChemistrySelect, 2023‏ - Wiley Online Library
The Nitroso entity, in its long history, has seen diverse applications in Chemistry, Biology
and Medicine. In numerous chemical reactions it has been considered mainly as an …