Molecular determinants of BK channel functional diversity and functioning

R Latorre, K Castillo… - Physiological …, 2017 - journals.physiology.org
Large-conductance Ca2+-and voltage-activated K+ (BK) channels play many physiological
roles ranging from the maintenance of smooth muscle tone to hearing and neurosecretion …

Ca2+-Activated K+ Channels: From Protein Complexes to Function

H Berkefeld, B Fakler, U Schulte - Physiological reviews, 2010 - journals.physiology.org
Molecular research on ion channels has demonstrated that many of these integral
membrane proteins associate with partner proteins, often versatile in their function, or even …

Building stable solid‐state potassium metal batteries

W Lyu, X Yu, Y Lv, AM Rao, J Zhou, B Lu - Advanced Materials, 2024 - Wiley Online Library
Solid‐state potassium metal batteries (SPMBs) are promising candidates for the next
generation of energy storage systems for their low cost, safety, and high energy density …

Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel

X Tao, RK Hite, R MacKinnon - Nature, 2017 - nature.com
Abstract The Ca2+-activated K+ channel, Slo1, has an unusually large conductance and
contains a voltage sensor and multiple chemical sensors. Dual activation by membrane …

Structural basis for gating the high-conductance Ca2+-activated K+ channel

RK Hite, X Tao, R MacKinnon - Nature, 2017 - nature.com
The precise control of an ion channel gate by environmental stimuli is crucial for the
fulfilment of its biological role. The gate in Slo1 K+ channels is regulated by two separate …

BK channel activation: structural and functional insights

US Lee, J Cui - Trends in neurosciences, 2010 - cell.com
The voltage-and Ca 2+-activated K+(BK) channels are involved in the regulation of
neurotransmitter release and neuronal excitability. Structurally, BK channels are …

BK channels: multiple sensors, one activation gate

H Yang, G Zhang, J Cui - Frontiers in physiology, 2015 - frontiersin.org
Ion transport across cell membranes is essential to cell communication and signaling.
Passive ion transport is mediated by ion channels, membrane proteins that create ion …

Challenges in the therapeutic targeting of KCa channels: From basic physiology to clinical applications

NTH Van, WK Kim, JH Nam - International Journal of Molecular Sciences, 2024 - mdpi.com
Calcium-activated potassium (KCa) channels are ubiquitously expressed throughout the
body and are able to regulate membrane potential and intracellular calcium concentrations …

[HTML][HTML] Large conductance, Ca2+-activated K+ channels (BKCa) and arteriolar myogenic signaling

MA Hill, Y Yang, SR Ella, MJ Davis, AP Braun - FEBS letters, 2010 - Elsevier
Myogenic, or pressure-induced, vasoconstriction is critical for local blood flow
autoregulation. Underlying this vascular smooth muscle (VSM) response are events …

An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing

J Yang, G Krishnamoorthy, A Saxena, G Zhang, J Shi… - Neuron, 2010 - cell.com
Ca 2+-activated BK channels modulate neuronal activities, including spike frequency
adaptation and synaptic transmission. Previous studies found that Ca 2+-binding sites and …