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Molecular determinants of BK channel functional diversity and functioning
Large-conductance Ca2+-and voltage-activated K+ (BK) channels play many physiological
roles ranging from the maintenance of smooth muscle tone to hearing and neurosecretion …
roles ranging from the maintenance of smooth muscle tone to hearing and neurosecretion …
Ca2+-Activated K+ Channels: From Protein Complexes to Function
H Berkefeld, B Fakler, U Schulte - Physiological reviews, 2010 - journals.physiology.org
Molecular research on ion channels has demonstrated that many of these integral
membrane proteins associate with partner proteins, often versatile in their function, or even …
membrane proteins associate with partner proteins, often versatile in their function, or even …
Building stable solid‐state potassium metal batteries
Solid‐state potassium metal batteries (SPMBs) are promising candidates for the next
generation of energy storage systems for their low cost, safety, and high energy density …
generation of energy storage systems for their low cost, safety, and high energy density …
Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel
X Tao, RK Hite, R MacKinnon - Nature, 2017 - nature.com
Abstract The Ca2+-activated K+ channel, Slo1, has an unusually large conductance and
contains a voltage sensor and multiple chemical sensors. Dual activation by membrane …
contains a voltage sensor and multiple chemical sensors. Dual activation by membrane …
Structural basis for gating the high-conductance Ca2+-activated K+ channel
RK Hite, X Tao, R MacKinnon - Nature, 2017 - nature.com
The precise control of an ion channel gate by environmental stimuli is crucial for the
fulfilment of its biological role. The gate in Slo1 K+ channels is regulated by two separate …
fulfilment of its biological role. The gate in Slo1 K+ channels is regulated by two separate …
BK channel activation: structural and functional insights
US Lee, J Cui - Trends in neurosciences, 2010 - cell.com
The voltage-and Ca 2+-activated K+(BK) channels are involved in the regulation of
neurotransmitter release and neuronal excitability. Structurally, BK channels are …
neurotransmitter release and neuronal excitability. Structurally, BK channels are …
BK channels: multiple sensors, one activation gate
Ion transport across cell membranes is essential to cell communication and signaling.
Passive ion transport is mediated by ion channels, membrane proteins that create ion …
Passive ion transport is mediated by ion channels, membrane proteins that create ion …
Challenges in the therapeutic targeting of KCa channels: From basic physiology to clinical applications
Calcium-activated potassium (KCa) channels are ubiquitously expressed throughout the
body and are able to regulate membrane potential and intracellular calcium concentrations …
body and are able to regulate membrane potential and intracellular calcium concentrations …
[HTML][HTML] Large conductance, Ca2+-activated K+ channels (BKCa) and arteriolar myogenic signaling
Myogenic, or pressure-induced, vasoconstriction is critical for local blood flow
autoregulation. Underlying this vascular smooth muscle (VSM) response are events …
autoregulation. Underlying this vascular smooth muscle (VSM) response are events …
An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing
Ca 2+-activated BK channels modulate neuronal activities, including spike frequency
adaptation and synaptic transmission. Previous studies found that Ca 2+-binding sites and …
adaptation and synaptic transmission. Previous studies found that Ca 2+-binding sites and …