Familial syndromes associated with testicular and paratesticular neoplasms: a comprehensive review

A Strakova-Peterikova, M Slisarenko, J Skopal… - Virchows Archiv, 2024 - Springer
A syndromic association between a subset of testicular/paratesticular neoplasms is well
established. Such examples include Carney complex and large cell calcifying Sertoli cell …

Contemporary updates on sex cord–stromal tumors of the testis

AM Acosta, MT Idrees, DM Berney… - Advances in Anatomic …, 2024 - journals.lww.com
Testicular sex cord–stromal tumors (TSCSTs) are relatively rare, representing~ 5% of
testicular neoplasms overall. Historically, TSCSTs have been classified into 3 major entities …

Genetic and epigenetic alterations in precursor lesions of endometrial endometrioid carcinoma

O Gotoh, Y Sugiyama, A Tonooka… - The Journal of …, 2024 - Wiley Online Library
The hyperplasia–carcinoma sequence is a stepwise tumourigenic programme towards
endometrial cancer in which normal endometrial epithelium becomes neoplastic through …

[HTML][HTML] Molecular biomarkers with potential clinical application in testicular cancer

J Lobo, AM Acosta, GJ Netto - Modern Pathology, 2023 - Elsevier
Testicular germ cell tumors (TGCTs) and sex cord-stromal tumors (SCSTs) are the most
common testicular neoplasms. The morphologic spectrum of such tumors is wide, with …

[HTML][HTML] Testicular neoplasms with sex cord and stromal components harbor a recurrent pattern of chromosomal gains

AM Acosta, LM Sholl, F Maclean, CS Kao, TM Ulbright - Modern Pathology, 2024 - Elsevier
A small subset of testicular sex cord-stromal tumors, designated as Sertoli-stromal cell
tumors (SSCTs), comprises a mixture of Sertoli, spindle, and/or Leydig cells. The …

Germline APC alterations may predispose to testicular sex cord-stromal tumors

S Siegmund, C Ricci, CS Kao, AR Sangoi… - The American Journal …, 2023 - journals.lww.com
Sertoli cell tumor is a type of testicular sex cord-stromal tumor (TSCST) typically driven by
gain-of-function CTNNB1 variants. Recently, molecular studies have identified TSCSTs …

Metastatic Testicular Sex Cord Tumor Harboring a EWSR1::ATF1 Gene Fusion—A Case Report of a Novel Neoplasm: “Inflammatory and Nested Testicular Sex Cord …

H Carrillo-Ng, L Arvanitis… - … Journal of Surgical …, 2024 - journals.sagepub.com
We present a case report of a 54-year-old male with a metastatic testicular sex cord tumor
harboring a EWSR1:: ATF1 gene fusion. The tumor displayed a solid and nested …

Deep learning-based classifier for carcinoma of unknown primary using methylation quantitative trait loci

A Walker, CS Fang, C Schroff, J Serrano… - … of Neuropathology & …, 2025 - academic.oup.com
Cancer of unknown primary (CUP) constitutes between 2% and 5% of human malignancies
and is among the most common causes of cancer death in the United States. Brain …

Sex Cord Stromal Tumors of the Testis: A Review with Molecular Updates

M Colecchia, M Fiorentino, C Ricci… - Surgical Pathology …, 2025 - surgpath.theclinics.com
This article reviews potential future changes in the classification of sex cord stromal tumors
(SCST). The most useful immunohistochemical stains are summarized, and recent …

Fluorescence in-situ hybridization assessment of spindle cell-rich testicular sex cord stromal tumors demonstrates multiple chromosomal gains across histologic …

AM Acosta, CDM Fletcher, LM Sholl… - Human Pathology, 2024 - Elsevier
Spindle cell-rich testicular sex cord-stromal tumors (TSCSTs) comprise a group that includes
mostly (but not exclusively): myoid gonadal stromal tumor (MGST), adult granulosa cell …