The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

Sarcopenic obesity is characterized by a concurrent decline in muscle mass and function,
along with increased adipose tissue. Sarcopenic obesity is a growing concern in older …

Dysfunction of the endothelial lining of lesion-prone areas of the arterial vasculature is an
important contributor to the pathobiology of atherosclerotic cardiovascular disease …

Significance: Recent clinical evidence identified anemia to be correlated with severe
complications of cardiovascular disease (CVD) such as bleeding, thromboembolic events …

One in 10 persons in the world aged 40 years and older will develop the syndrome of
HFpEF (heart failure with preserved ejection fraction), the most common form of chronic …

In primary prevention, regular physical activity decreases the incidence of cardiovascular
disease. At the endothelial level, this decreased incidence was attributed to higher …

Excessive reactive oxygen species Revised abstract, especially superoxide anion (O2•−),
play important roles in the pathogenesis of many cardiovascular diseases, including …

Nitric oxide (NO) produced by the endothelial NO synthase (eNOS) is a fundamental
determinant of cardiovascular homesotasis: it regulates systemic blood pressure, vascular …

Free radicals and other reactive oxygen species (ROS) are constantly formed in the human
body. Free‐radical mechanisms have been implicated in the pathology of several human …

Mechanical forces associated with blood flow play important roles in the acute control of
vascular tone, the regulation of arterial structure and remodeling, and the localization of …