Toxoplasmosis is caused by Toxoplasma gondii, an apicomplexan parasite that is able to
infect any nucleated cell in any warm-blooded animal. Toxoplasma gondii infects around 2 …

Toxoplasma gondii causes fatal and debilitating brain and eye diseases. Medicines that are
currently used to treat toxoplasmosis commonly have toxic side effects and require …

The first full publications on the biological effects of the diphosphonates, later renamed
bisphosphonates, appeared in 1969, so it is timely after 40 years to review the history of their …

Bisphosphonates (BP) are a class of calcium-binding drug used to prevent bone resorption
in skeletal disorders such as osteoporosis and metastatic bone disease. They act by …

R-Aminophosphonic acids are broadly defined as analogues of amino acids in which the
carboxylic group is replaced by a phosphonic acid or related group (usually phosphonous or …

Although the phosphorus atom is found in a variety of oxidation states, most of the
phosphorus‐containing molecules of pharmacological importance possess phosphorus in …

This review describes the key discoveries over the last 15 years that have led to a clearer
understanding of the molecular mechanisms by which bisphosphonate drugs inhibit bone …

In this" Critical Review" we made a historical introduction of drugs assayed against Chagas
disease beginning in 1912 with the works of Mayer and Rocha Lima up to the experimental …

The chemotherapy currently available for leishmaniasis is far from satisfactory. Resistance to
the pentavalent antimonials, which have been the recommended drugs for the treatment of …

Many first-line treatments for neglected tropical diseases identified by the World Health
Organization (WHO) are limited by one or more of the following: the development of drug …