Oxygen is indispensable to metabolism and energy production for almost all life forms.
However, reactive oxygen species (ROS) generated from life processes can cause damage …

Background Free radical-mediated lipid peroxidation has been implicated in a number of
human diseases. Diverse methods have been developed and applied to measure lipid …

Oxysterols are oxygenated derivatives of cholesterol formed in the human body or ingested
in the diet. By modulating the activity of many proteins [eg, liver X receptors (LXRs), oxysterol …

Cholesterol has many functions, including those that affect biophysical properties of
membranes, and is a precursor to hormone synthesis. These actions are governed by …

Primary cilia are required for Smoothened to transduce vertebrate Hedgehog signals, but
how Smoothened accumulates in cilia and is activated is incompletely understood. Here, we …

In the present study, we discuss the recent developments in oxysterol research. Exciting
results have been reported relating to the involvement of oxysterols in the fields of …

Ferroptosis is a form of regulated cell death driven by lipid peroxidation of polyunsaturated
fatty acids (PUFAs). Lipid peroxidation can propagate through either the hydrogen-atom …

Ion mobility-mass spectrometry (IM-MS) has proven to be a highly informative technique for
the characterization of lipids from cells and tissues. We report the combination of hydrophilic …

Cholesterol is a unique lipid molecule providing the building block for membranes,
hormones, vitamin D and bile acid synthesis. Metabolism of cholesterol involves several …

This Perspective describes advances from the author's laboratory on the free radical
reactions of organic compounds with molecular oxygen. Polyunsaturated fatty acids (PUFAs) …