Complex biological systems and cellular networks may underlie most genotype to
phenotype relationships. Here, we review basic concepts in network biology, discussing …

A central goal of systems biology is to elucidate the structural and functional architecture of
the cell. To this end, large and complex networks of molecular interactions are being rapidly …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

Transcription regulation networks control the expression of genes. The transcription
networks of well-studied microorganisms appear to be made up of a small set of recurring …

“But although, as a matter of history, statistical mechanics owes its origin to investigations in
thermodynamics, it seems eminently worthy of an independent development, both on …

A cell's behavior is a consequence of the complex interactions between its numerous
constituents, such as DNA, RNA, proteins and small molecules. Cells use signaling …

Background: Most successful computational approaches for protein function prediction
integrate multiple genomics and proteomics data sources to make inferences about the …

An extracellular matrix composed of a layered meshwork of β-glucans, chitin, and
mannoproteins encapsulates cells of the yeast Saccharomyces cerevisiae. This organelle …

Various technologies can be used to produce genome-scale, or'omics', data sets that
provide systems-level measurements for virtually all types of cellular components in a model …

Many disease states result from gene overexpression, often in a specific genetic context. To
explore gene overexpression phenotypes systematically, we assembled an array of 5280 …