Physiology and pathophysiology of human airway mucus

DB Hill, B Button, M Rubinstein… - Physiological …, 2022 - journals.physiology.org
The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

The role of mucosal barriers in disease progression and transmission

NA Bustos, K Ribbeck, CE Wagner - Advanced Drug Delivery Reviews, 2023 - Elsevier
Mucus is a biological hydrogel that coats and protects all non-keratinized wet epithelial
surfaces. Mucins, the primary structural components of mucus, are critical components of the …

The yielding behaviour of human mucus

D Kavishvar, A Ramachandran - Advances in Colloid and Interface Science, 2023 - Elsevier
Mucus is a viscoelastic material with non-linear rheological properties such as a yield stress
of the order of a few hundreds of millipascals to a few tens of pascals, due to a complex …

Modulation of engineered nanomaterial interactions with organ barriers for enhanced drug transport

V Lenders, X Koutsoumpou, P Phan… - Chemical Society …, 2023 - pubs.rsc.org
The biomedical use of nanoparticles (NPs) has been the focus of intense research for over a
decade. As most NPs are explored as carriers to alter the biodistribution, pharmacokinetics …

[HTML][HTML] Computational analysis of obstructive disease and cough intensity effects on the mucus transport and clearance in an idealized upper airway model using the …

H Yi, Q Wang, Y Feng - Physics of Fluids, 2021 - pubs.aip.org
This study provides a quantitative analysis to investigate the effects of cough intensity and
initial mucus thickness on the mucus transport and clearance in a mouth-to-trachea airway …

An optimized protocol for assessment of sputum macrorheology in health and muco-obstructive lung disease

M Völler, A Addante, H Rulff, B von Lospichl… - Frontiers in …, 2022 - frontiersin.org
Background: Airway mucus provides important protective functions in health and abnormal
viscoelasticity is a hallmark of muco-obstructive lung diseases such as cystic fibrosis (CF) …

Effect of inhaled air temperature on mucus dynamics in the proximal airways

R Patne - Journal of Fluid Mechanics, 2024 - cambridge.org
The aim of the present study is to understand the role of steam/cold-air inhalation on the
mucus layer dynamics in the proximal airways. We model these flows as a viscoelastic liquid …

Comprehensive analysis of heat and water exchanges in the human lungs

B Haut, A Nonclercq, A Buess, J Rabineau… - Frontiers in …, 2021 - frontiersin.org
This work presents a new mathematical model of the heat and water exchanges in the
human lungs (newborn to adult). This model is based on a local description of the water and …

Cilia and centrosomes: Ultrastructural and mechanical perspectives

T Ishikawa, H Ueno, T Omori, K Kikuchi - Seminars in Cell & …, 2021 - Elsevier
Cilia and centrosomes of eukaryotic cells play important roles in cell movement, fluid
transport, extracellular sensing, and chromosome division. The physiological functions of …

Insights into the fluid dynamics of bioaerosol formation in a model respiratory tract

S Saha, MK Manna, A Chakravarty, S Sarkar… - …, 2024 - pubs.aip.org
Bioaerosols produced within the respiratory system play an important role in respiratory
disease transmission. These include infectious diseases such as common cold, influenza …