Cardiovascular disease is the leading cause of death in western countries. Among
cardiovascular diseases, myocardial infarction represents a life-threatening condition …

Heart diseases due to myocardial ischemia, such as myocardial infarction or ischemic heart
failure, are major causes of death in developed countries, and their number is unfortunately …

Cardiomyocytes are one of the most mitochondria-rich cell types in the body, with∼ 30–40%
of the cell volume being composed of mitochondria. Mitochondria are well established as …

Reperfusion may induce additional cell death in patients with acute myocardial infarction
receiving primary angioplasty or thrombolysis. Altered intracellular Ca2+ handling was …

As of yet, only a few strategies to prevent myocardial reperfusion injury have been tested
clinically. In the first minutes of reperfusion, the myocardium can be damaged by contracture …

ATP-sensitive potassium (KATP) channels are present in the surface and internal
membranes of cardiac, skeletal, and smooth muscle cells and provide a unique feedback …

Pathological conditions linked to imbalances in oxygen supply and demand (for example,
ischaemia, hypoxia and heart failure) are associated with disruptions in intracellular sodium …

During the past decade, the understanding has grown that control of the conditions of
reperfusion is critical for salvaging ischemic–reperfused myocardium. The first few minutes …

Reperfusion of ischemic myocardium is required for tissue survival; however, reperfusion
elicits pathologic consequences. Myocardial reperfusion injury is a multifarious process that …

The principal therapy in patients with myocardial infarction to limit infarct size is myocardial
reperfusion by mechanical or pharmacological intervention. Reperfusion has been …