As the median age of the population increases, the number of individuals with Alzheimer's
disease (AD) and the associated socio-economic burden are predicted to worsen. While …

Copper is an essential element in cells; it can act as either a recipient or a donor of
electrons, participating in various reactions. However, an excess of copper ions in cells is …

Alzheimer's disease (AD) is an irreversible, age-related progressive neurological disorder,
and the most common type of dementia in aged people. Neuropathological lesions of AD …

Significance: Alzheimer's disease (AD) is the most common cause of dementia in the elderly.
AD is currently ranked as the sixth leading cause of death, but some sources put it as third …

Cu/Zn superoxide dismutase (SOD1) is a frontline antioxidant enzyme catalysing superoxide
breakdown and is important for most forms of eukaryotic life. The evolution of aerobic …

The abnormal aggregation of β-amyloid protein (Aβ) is a major contributor to Alzheimer's
disease (AD). Cu 2+ homeostasis imbalance can lead to the aggregation of Aβ, resulting in …

Metal ions play a key role in aggregation of amyloid β protein by interfering with their proper
folding, altering protein homeostasis and cell viability, and ultimately leading to …

Copper is an essential trace element, and plays a vital role in numerous physiological
processes within the human body. During normal metabolism, the human body maintains …

The copper compound CuII (atsm) has progressed to phase 2/3 testing for treatment of the
neurodegenerative disease amyotrophic lateral sclerosis (ALS). CuII (atsm) is …

Evidence of copper's (Cu) involvement in Alzheimer's disease (AD) is available, but
information on Cu involvement in microglia and astrocytes during the course of AD has yet to …